Saw Palmetto

(BANM, rINNM)

💊 Chemical information

American Dwarf Palm; Brahea serrulata; PA-109; Palmera de Florida; Sabal; Sabal, fruit de (saw palmetto fruit); Sabal serrulata; Sabalis Serrulatae; Sabalis serrulatae fructus (saw palmetto fruit); Sågpalmettofrukt (saw palmetto fruit); Sahapalmunhedelmä (saw palmetto fruit); Serenoa repens; Serenoa serrulatum; Serenový plod (saw palmetto fruit); Šliaužiančiu ju serenoju vaisiai (saw palmetto fruit).
ATC — G04CX02.
ATC Vet — QG04C X02.

Pharmacopoeias.

In Eur. and US. US also includes the extract and the powdered form.

Ph. Eur. 6.2

(Saw Palmetto Fruit). The dried, ripe fruit of Ser enoa repens (Sabal serrulata). It contains not less than 11.0% of total fatty acids, calculated with reference to the dried drug. Protect from light.

USP 31

(Saw Palmetto). The partially dried, ripe fruit of Serenoa repens (Arecaceae). Store in airtight containers. Protect from light.

💊 Profile

Saw palmetto is the dried fruit of the American dwarf palm tree, Serenoa repens (Arecaceae). It contains various steroidal compounds with anti-androgenic and oestrogenic activities, one of which is sitosterol. Saw palmetto is used for the treatment of benign prostatic hyperplasia. Preparations of alcoholic or lipophilic extracts have typically been given in oral doses of 160 mg twice daily, or 320 mg once daily.

Adverse effects.

EFFECTS ON THE LIVER. Cholestatic hepatitis occurred in a man who took a herbal preparation containing saw palmetto for 2 weeks to treat nocturia and hesitancy.1
1. Hamid S, et al. Protracted cholestatic hepatitis after the use of Prostata. Ann Intern Med 1997; 127: 169–70.

Uses.

BENIGN PROSTATIC HYPERPLASIA. A lipid hexane extract of saw palmetto has been shown to be generally superior to placebo,1,2 and of similar efficacy to finasteride3 in the treatment of benign prostatic hyperplasia. A systematic review of randomised studies of various saw palmetto extracts concluded that they improve urological symptoms and flow measures.4 However, a more recent double-blind study5concluded that treatment for one year was not superior to placebo for improving urinary symptoms and objective measures.
1. Champault G, et al. A double-blind trial of an extract of the plant Serenoa repens in benign prostatic hyperplasia. Br J Clin Pharmacol 1984; 18: 461
2. Plosker GL, Brogden RN. Serenoa repens (Permixon): a review of its pharmacology and therapeutic efficacy in benign prostatic hyperplasia. Drugs Aging 1996; 9: 379–95
3. Carraro J-C, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996; 29: 231–40
4. Wilt T, et al. Serenoa repens for benign prostatic hyperplasia. Available in The Cochrane Database of Systematic Reviews; Issu
3. Chichester: John Wiley; 2002 (accessed 29/11/05)
5. Bent S, et al. Saw palmetto for benign prostatic hyperplasia. N Engl J Med 2006; 354: 557–66.

💊 Preparations

USP 31: Saw Palmetto Capsules.

Proprietary Preparations

Arg.: Beltrax Uno; Herbaccion Prostatico†; Permicaps; Permixon; Sereprostat†; Austral.: Bioglan Pro-Guard; Prosta†; Austria: Permixon; Prosta-Urgenin; Belg.: Prosta-Urgenin; Prostaserene; Braz.: Permixon†; Prostalium†; Prostat; Prostatal; Renopen; Chile: Prostafort; Cz.: Capistan; Prosta-Urgenin; Prostakan Mono; Prostamol Uno; Spalda Sabal; Fr.: Permixon; Ger.: Azuprostat Sabal†; Eviprostat-S; Hyperprost Uno; Normurol†; Planturol†; Prosta Urgenin Uno; Prostagutt mono; Prostagutt uno; Prostaplant†; Prostess; Remiprostan uno; Sabacur uno; Sabal; Sabal uno; Sabalvit; Sabonal Uno†; Sita; Steiprostat; Strogen; Talso; Gr.: Libeprosta; Urisedon†; Hung.: Prostakan†; Prostamol Uno; Saballo; Strogen Uno; Indon.: Lanaprost; Prostakur; Israel: Permixon; Ital.: Biosern†; Permixon; Prosteren; Rilaprost; Saba; Serpens; Mex.: Permixon; Prostasan; Prostex; Urogutt; Pol.: Bioprost; Fitoprost; Permixon; Prostamol Uno; Prostaplant; Sterko; Port.: Permixon; Prostiva†; Sereprosta; Rus.: Permixon (Пермиксон); Prostamol Uno (Простамол Уно); Prostaplant (Простаплант); Singapore: Permixon; Spain: Permixon; Sereprostat; Switz.: Permixon; Prosta-Urgenine; ProstaMed; Prostasan; SabCaps; Thai.: Permixon; Urogutt; UK: Prostasan; Sabalin; Venez.: Permixon†. Multi-ingredient: Arg.: Anastim con RTH; Argeal; Catiz Plus; Keracnyl; Normoprost Plus; PR21; Sabal; Ultracal; Austral.: Bioglan Mens Super Soy/Clover; Extralife Flow-Care; Lifechange Mens Complex with Saw Palmetto†; Serenoa Complex†; Urapro†; Urgenin†; Urinase†; Austria: Prostagutt; Spasmo-Urgenin; Urgenin; Belg.: Urgenin; Canad.: Damiana-Sarsaparilla Formula†; Prostate Ease; Prostease; ProstGard†; Cz.: Prostakan Forte; Fr.: Argeal; Kelual DS; Keracnyl; Sabal; Ger.: Cefasabal; Granu Fink Prosta; Nephroselect M; Prostagutt forte; Hong Kong: Palmetto Plus†; Phyto-Ease; Prostease; Sawmetto Vivo-Livo†; Urgenin; Indon.: Instink; Maxirex; Menolia; Reximax; Soprost; Israel: Urgenin; Ital.: Biothymus M Urto; Pluvio; Prostaplant; Malaysia: Prostakan†; Total Man†; Mex.: Prosgutt; Pol.: Naturapia Prostata; Penigra; Port.: Efluvium Anti-caspa; Efluvium Anti-seborreico; Neo Urgenin; Spasmo-Urgenin†; Rus.: Prostagutt Forte (Простагут Форте); S.Afr.: Spasmo-Urgenin†; Singapore: Palmetto Plus; Spain: Neo Urgenin; Spasmo-Urgenin; Urgenin; Switz.: Granu Fink Prosta; Phytomed Prosta†; Prosta-Caps Chassot N; Prostagutt-F; Thai.: SpasmoUrgenin; UK: Antiglan; Daily Fatigue Relief; Damiana and Kola Tablets; Elixir Damiana and Saw Palmetto; Regina Royal Concorde; Strength; Venez.: Sabal.
Published November 19, 2018.