Valerian

(pINN)

💊 Chemical information

Baldrianwurzel; Korzeń kozłka; Kozlíkový kořen; Macskagyökér; Valer; Valeriaananjuuri; Valerian Rhizome; Valerian Root; Valeriana; Valerianae radix; Valerianarot; Valériane, racine de; Valerijonu šaknys.
CAS — 8057-49-6 (valerian extract).
ATC — N05CM09.
ATC Vet — QN05CM09.

Pharmacopoeias.

In Eur. and US. Eur. also includes valerian dry hydroalcoholic extract and tincture. US. includes the powdered form. Jpn has Japanese Valerian from V. fauriei.

Ph. Eur. 6.2

(Valerian Root; Valerian BP 2008). The yellowishgrey to pale brownish-grey whole underground parts of Va l er i ana officinalis, including the rhizome surrounded by the roots and stolons, or by fragments of these parts. It contains not less than 0.4% v/w of essential oil for the whole drug and not less then 0.3% v/w for the cut drug, both calculated with reference to the dried drug. Protect from light.

USP 31

(Valerian). The subterranean parts of Valeriana officinalis (Valerianaceae), including the rhizome, roots, and stolons. It contains not less than 0.5% of volatile oil and not less than 0.05% of valerenic acid, calculated on the dried basis. Store in airtight containers. Protect from light.

💊 Profile

Valerian has sedative properties and is used as an extract, infusion, or tincture, or occasionally as the dried root, in preparations for anxiety states. It has also been used as a carminative. Valerian oil is used in aromatherapy. The odour of valerian may be removed from the skin and from hard surfaces with sodium bicarbonate.
1. Houghton P. Valerian. Pharm J 1994; 253: 95–6
2. Houghton PJ. The scientific basis for the reputed activity of valerian. J Pharm Pharmacol 1999; 51: 505–12
3. Plushner SL. Valerian: valeriana officinalis. Am J Health-Syst Pharm 2000; 57: 328–35
4. Stevinson C, Ernst E. Valerian for insomnia: a systematic review of randomized clinical trials. Sleep Med 2000; 1: 91–9
5. Bent S, et al. Valerian for sleep: a systematic review and metaanalysis. Am J Med 2006; 119: 1005–12.

Adverse effects.

Liver damage1 was reported in 4 patients who took herbal stress remedies that contained valerian. Cardiac complications and delirium in a 58-year-old man may have been caused by the withdrawal of prolonged therapy with a valerian root extract preparation.2
1. MacGregor FB, et al. Hepatotoxicity of herbal remedies. BMJ 1989; 299: 1156–7
2. Garges HP, et al. Cardiac complications and delirium associated with valerian root withdrawal. JAMA 1998; 280: 1566–7.

💊 Preparations

Ph. Eur.: Valerian Dry Hydroalcoholic Extract; Valerian Tincture; USP 31: Valerian Tablets.

Proprietary Preparations

Arg.: Nervisatis; Sedante Nativa†; Austral.: Herbal Sleep Formula†; Austria: Baldrinetten†; Belg.: Dormiplant; Relaxine; Valdispert†; Valerial; Braz.: Noctaval; Recalm; Sonoripan; Traminer; Valdorm; Valeriane; Valerimed; Valerin; Valerix; Valezen; Valmane; Canad.: Nytol Natural Source; Sleep-Eze V Natural; Unisom Natural Source†; Chile: Sominex; Cz.: Koren Kozliku Lekarskeho†; Kozlik; Valdispert†; Fin.: Valrian; Ger.: Baldorm; Baldriparan Stark†; Baldrivit; Baldurat; Cefaluna†; Cefan; Dolestan; Euvegal Balance; Kytta-Sedativum; Luvased mono; Phytodorma†; Recvalysat†; Sedonium; Sporal mono; Valdispert†; Hong Kong: Cirku Sed†; Israel: Relaxine; Valeton; Ital.: Ticalma; Val-Uno†; Mex.: Neolaikan; Neth.: Dormiplant; Sedonium; Valdispert; Pol.: Cirkused; Relana Forte; Valerin; Port.: Valdispert; Valditas; Rus.: Novo-Passit (Ново-Пассит); S.Afr.: Calmettes; Spain: Ansiokey; Cirkused†; Coenrelax; Tauval†; Valdispert; Valeriana Orto; Valsedan; Swed.: Baldrian-Dispert; Neurol; Valerecen; Switz.: Baldriparan pour la nuit; Baldrisedon†; Natu-Seda; Plantival Mono†; ReDormin; Sedasol eco natura; Sedonium; Sirop pour le sommeil†; Valdispert; Valverde Sommeil†; UK: Niteherb; Phytorelax; Sedonium; Venez.: Floral Pas. Multi-ingredient: Arg.: Armonil; Calmtabs†; Dioxicolagol; Erbonda Noche†; Herbaccion Sedante†; Incaico Serenidad; Insomnal†; Nervocalm; SDN 200; Sedanat; Sedante Arceli†; Sedante Dia; Serenil; Sigmasedan; Top Life Relax†; Trixol†; Valeriana Diates; Valeriana Oligoplex; Valeriana Relax Diates; Austral.: Calmo; Coleus Complex; Dan Shen Compound; Executive B; Extralife Sleep-Care; Goodnight Formula†; Humulus Compound; Lifesystem Herbal Plus Formula 2 Valerian†; Macro Anti-Stress†; Multi-Vitamin Day & Night†; Natural Deep Sleep; Pacifenity†; Passiflora Complex†; Passionflower Plus; Prosed-X†; ReDormin; Relaxaplex†; Valerian Plus Herbal Plus Formula 12†; Valerian†; Austria: Baldracin; Baldrian AMA; Eryval; Euvekan; Hova; Nervenruh; Nerventee St Severin; Sedadom; Sedogelat; Songha; Species nervinae; Thymoval; Valin Baldrian; Wechseltee St Severin; Belg.: Natudor; Seneuval; Songha; Braz.: Anevrase†; Passicalm†; Remilev; Sominex; Sonhare; Canad.: Herbal Nerve; Herbal Sleep Well†; Relax and Sleep; Chile: Armonyl; Recalm; Valupass; Cz.: Baldracin; Bio-Strath†; Contraspan†; Dr Theiss Rheuma Creme†; Dr Theiss Schwedenbitter; Euvekan; Hertz- und Kreislauftee†; Hova; Klosterfrau Beruhigungs Forte†; Nervova Cajova Smes; Novo-Passit; Persen; Sanason; Schlaf-Nerventee N†; Songha Night†; Species Nervinae Planta; Valofyt Neo; Visinal†; Fr.: Anxoral†; Biocarde; Euphytose; Mediflor Tisane Calmante Troubles du Sommeil No 14; Mediflor Tisane Circulation du Sang No 12; Neuroflorine; Palpipax†; Passinevryl; Phytocalm†; Spasmine; Sympaneurol; Tranquital; Ger.: Alluna Nacht; Ardeysedon; Avedorm duo; Baldrian-Dispert Nacht; Baldriparan N Stark†; Biosedon†; Boxocalm; Cefasedativ†; Cor-Select†; Dormarist†; Dormeasan; Dormo-Sern†; Dormoverlan; Dr. Scheffler Bergischer Krautertee Nerven- und Beruhigungstee; Dreierlei; Euvegal; Euvegal Entspannungsund Einschlafdragees†; Euvegal Entspannungs- und Einschlaftropfen; Gutnacht†; Habstal-Nerv N†; Heumann Beruhigungstee Tenerval; HingfongEssenz Hofmanns; Hyperesa; JuDorm†; Kavosporal comp†; Kneipp Gute Nacht; Kytta-Sedativum; Leukona-Beruhigungsbad†; Lomasleep†; Luvased; Majocarmin mite†; Moradorm S; Mutellon; Nervendragees†; Nervenkapseln; Nervoregin forte†; Nervoregin phyto; Nervosana†; Neurapas; Nitrangin compositum†; Oxacant N†; Oxacant-sedativ; Pascosedon; Phytonoctu; Plantival novo; Presselin Nerven K 1 N†; Pronervon Phyto; Psychotonin-sed; Rhoival†; RubieSed†; Schlaf- und Nerventee; Schwedentrunk Elixier; Seda-Plantina†; Sedacur; Sedariston Konzentrat; Sedariston plus; Sedaselect D; Sedasyx†; Sedinfant N†; Selon; Sensinerv forte†; Somnuvis S†; Tornix; Valdispert comp†; Valeriana comp novum; Valeriana forte N†; Valeriana mild†; Valverde Baldrian Hopfen bei Einschlafstorungen und zur Beruhigung†; Vivinox Day; Hong Kong: Epizon†; Hung.: Euvekan; Hova; ReDormin; Sedacur; India: Well-Beeing†; Indon.: Slip-iZZZ; Israel: Calmanervin; Nerven-Dragees; Passiflora; Passiflora Compound; Songha Night; Ital.: Anevrasi; Bianco Val†; Biocalm; Calmason; Camomilla (Specie Composta)†; Dormiplant; Fitosonno; Florelax; Glicero-Valerovit; Melissa (Specie Composta)†; Noctis; Parvisedil; Reve; Sedatol; Sedopuer F; ValPlus†; Valeriana (Specie Composta)†; Mex.: Ivel; Nervinetas; Pasinordin; Plantival; Pol.: Calmina; Cardiol C; Cardiotonic; Cholitol; Dormiplant; Fortestomachicae; Guttae Stomachicae; Hova; Kalms; Krople Zoladkowe; Lekosen; Lumewal; Neocardina; Neospasmina; Neospasmol; Nervendragees; Nervomix; Nervosol; Nerwobonisol; Passispasmin; Passispasmol; Persen; Prostapol; Relana; Sedomix; Tabletki Uspokajajace; Uroprost; Vallup; Valused; Port.: Antispasmina Colica; Gabisedil†; Neurocardol†; Songha†; Valesono†; Rus.: Doppelherz Vitalotonik (Доппельгерц Виталотоник); Herbion Drops for the Heart (Гербион Сердечные Капли); Insti (Инсти); Passifit (Пассифит); Persen (Персен); Sanason (Санасон); S.Afr.: Avena Sativa Comp; Biral; Entressdruppels HM; Helmontskruie; Krampdruppels; Restin; Stuidruppels; Wonderkroonessens; Spain: Dormiplant; Melival; Natusor Somnisedan†; Nervikan; Relana; Sedasor†; Sedonat; Valdispert Complex; Switz.: Baldriparan; Baldrisedon plus†; Dicalm†; Dormeasan; Dormiplant; Dragees pour la detente nerveuse; Dragees pour le coeur et les nerfs; Dragees pour le sommeil; Dragees sedatives Dr Welti; Hova; Nervinetten; Perpector†; Phytomed Somni†; ReDormin; Relaxane; Relaxo; Songha Night; Soporin; Strath Gouttes pour le nerfs et contre l’insomnie; Tisane calmante pour les enfants; Tisane pour le sommeil et les nerfs; Tisane relaxante N†; Valverde Coeur; Valverde Detente dragees; Valverde Sommeil; Valviska; Zeller Sommeil; UK: Avena Sativa Comp; Bio-Strath Valerian Formula; Daily Tension & Strain Relief; Digestive; Gerard House Serenity; Gerard House Somnus; Herbal Indigestion Naturtabs; Herbal Pain Relief; HRI Calm Life; HRI Golden Seal Digestive; HRI Night; Indigestion and Flatulence; Kalms; Kalms Sleep; Laxative Tablets; Menopause Relief; Modern Herbals Stress; Natrasleep; Natural Herb Tablets; Newrelax; Niteherb Plus; Nodoff; Nytol Herbal; Period Pain Relief; PMT Formula; Prementaid; Quiet Days; Quiet Life; Quiet Nite; Quiet Tyme; Relax B ; Scullcap & Gentian Tablets; Sominex Herbal; Stressless; SuNerven; Sure-Lax (Herbal); Tranquil; Unwind Herbal Nytol; Valerina Day Time; Valerina Night-Time; Vegetable Cough Remover; Wellwoman; Wind & Dyspepsia Relief; Venez.: Cratex†; Equaliv; Eufytose†; Euvekan; Femendol; Insocaps; Lupassin; Nervinetas; Pasidor; Pasifluidina; Rendetil; Sedival.
Published May 08, 2019.