Uridine Triphosphate

(USAN)
Synonyms: Ins-316; Trifosfato de uridina; Uridina trifosfato; Uridine Triphosphoric Acid; UTP. Uridine 5′-(tetrahydrogen triphosphate).
Cyrillic synonym: Уридин Трифосфат.

💊 Chemical information

Chemical formula: C9H15N2O15P3 = 484.1.
CAS — 63-39-8.

💊 Profile

Uridine triphosphate is an endogenous uracil nucleotide involved in many biological processes. It has been claimed to be of value in muscular atrophy and muscular weakness, and has been included in preparations for neuralgia, neuritis, and muscular disorders; the disodium and trisodium salts have also been used. It may, however, have a role as a method of producing deep-lung sputum specimens for cytological evaluation and is being investigated as an aid to the diagnosis of for example, lung cancer1,2 or airway inflammation in asthma.3
1. Bennett WD, et al. Effect of aerosolized uridine 5’-triphosphate on mucociliary clearance in mild chronic bronchitis. Am J Respir Crit Care Med 2001; 164: 302–6
2. Johnson FL, et al. Improved sputum expectoration following a single dose of INS316 in patients with chronic bronchitis. Chest 2002; 122: 2021–9
3. Tamaoki J, et al. Validity and safety of sputum induction by inhaled uridine 5′-triphosphate. Am J Respir Crit Care Med 2001; 164: 378–81.

💊 Preparations

Proprietary Preparations

Fr.: Uteplex; Ital.: Miocuril†. Multi-ingredient: Arg.: Nucleo CMP†; Braz.: Nucleo CMP; Chile: Citoneuron; Ital.: Fosfoutipi Vitaminico†; Mex.: Nucleo CMP; Spain: Cefabol; Nucleo CMP; Taurobetina†.
Published May 08, 2019.