💊 Chemical information
Tiramina, hidrocloruro de; p-Tyramine Hydrochloride; Tyrosamine Hydrochloride. 4-Hydroxyphenethylamine hydrochloride; 4-(2-Aminoethyl)phenol hydrochloride.
Chemical formula: C8H11NO,HCl = 173.6.
CAS — 51-67-2 (tyramine); 60-19-5 (tyramine hydrochloride).
Tyramine hydrochloride is a sympathomimetic with indirect effects on adrenergic receptors. It has been given orally or by injection in the tyramine pressor test for the investigation of monoamine oxidase inhibitory activity or amine uptake blocking activity. It has also been used in studies of physiological and disease states, and in the diagnosis of migraine and phaeochromocytoma. The hazards of taking foods rich in tyramine while under treatment with MAOIs are described in the chapter on Antidepressants.
◊ The bioavailability of tyramine given by mouth is significantly reduced by the presence of food, which could have implications when used in tyramine pressor tests.1
1. VanDenBerg CM, et al. Tyramine pharmacokinetics and reduced bioavailability with food. J Clin Pharmacol 2003; 43: 604–9.
Multi-ingredient: Ger.: Mydrial-Atropin†.
Published May 08, 2019.