Tucaresol Chemical formula
Synonyms: BW-589C; 589C; 589C80; Tucarésol; Tucaresolum. α-(2-Formyl3-hydroxyphenoxy)p-toluic acid.
Cyrillic synonym: Тукарезол.

Chemical information

Chemical formula: C15H12O5 = 272.3.
CAS — 84290-27-7.


Tucaresol is reported to interact with haemoglobin to increase oxygen affinity. It has been investigated as an oral drug for the treatment of sickle-cell disease. Tucaresol is also reported to have immunostimulant properties and is under investigation in HIV infection and hepatitis B. Hypersensitivity reactions have occurred.
1. Rolan PE, et al. The pharmacokinetics, tolerability and pharmacodynamics of tucaresol (589C80; 4[2-formyl-3-hydroxyphenoxymethyl]benzoic acid), a potential anti-sickling agent, following oral administration to healthy subjects. Br J Clin Pharmacol 1993; 35: 419–25
2. Arya R, et al. Tucaresol increases oxygen affinity and reduces haemolysis in subjects with sickle cell anaemia. Br J Haematol 1996; 93: 817–21
3. Peck RW, et al. Effect of food and gender on the pharmacokinetics of tucaresol in healthy volunteers. Br J Clin Pharmacol 1998; 46: 83–6
4. Gori A, et al. Immunomodulation induced by tucaresol in HIV infection: results of a 16 week pilot Phase I/II trial. Antivir Ther 2004; 9: 603–14.
Published May 08, 2019.