Trypsin

(BAN)

💊 Chemical information

Thrypsinum; Tripsina; Tripsinas; Tripszin; Trypsiini; Trypsine; Tr ypsinum; Tr ypsyna.
CAS — 9002-07-7.
ATC — B06AA07; D03BA01.
ATC Vet — QB06AA07; QD03BA01.

Pharmacopoeias.

In Chin., Eur., and US.

Ph. Eur. 6.2

(Trypsin). A proteolytic enzyme obtained by the activation of trypsinogen extracted from mammalian pancreas. It has an activity of not less than 0.5 microkatals/mg, calculated with reference to the dried substance. A white or almost white, crystalline or amorphous powder; the amorphous form is hygroscopic. Sparingly soluble in water. A 1% solution in water has a pH of 3.0 to 6.0. Solutions have a maximum stability at pH 3 and a maximum activity at pH 8. Store at 2° to 8° in airtight containers. Protect from light.

USP 31

(Crystallized Trypsin). A proteolytic enzyme crystallised from an extract of the pancreas of healthy bovine or porcine animals, or both. It contains not less than 2500 USP units in each mg, calculated on the dried basis. A white to yellowish-white, odourless, crystalline or amorphous powder. Store in airtight containers at temperature not exceeding 40°.

💊 Profile

Trypsin is a proteolytic enzyme that has been applied for the debridement of wounds. It has also been taken by mouth, usually with chymotrypsin, and sometimes with antibacterial or other drugs, for its supposed benefit in relieving oedema and inflammation associated with infection or trauma. Trypsin solutions have been inhaled for the liquefaction of viscous sputum, and trypsin is also an ingredient of mixtures intended to relieve various gastrointestinal disorders. Trypsin has been used in oncology in a combination preparation with chymotrypsin and papain. Hypersensitivity reactions may occasionally occur.

💊 Preparations

Proprietary Preparations

Multi-ingredient: Arg.: Phlogenzym†; Austria: Leukase; Leukase-Kegel; Phlogenzym; Rutozym; Traumazym; Wobenzym; Braz.: Parenzyme; Parenzyme Ampicilina; Parenzyme Analgesico; Parenzyme Tetraciclina; Cz.: Phlogenzym; Wobe-Mugos†; Wobenzym; Fr.: Ribatran; Ger.: Enzym-Wied†; Mulsal N†; Phlogenzym; Wobe-Mugos E†; Wobenzym N†; Gr.: Chymoral; Hung.: Phlogenzym; Trypsin†; India: Alfapsin; Orthal Forte; Soluzyme; Ital.: Essen Enzimatico†; Jpn: Kimotab; Mex.: Ochozim; Phlogenzym; Quimotrip; Ribotripsin; Wobe-Mugos; Wobenzym; Zimotris; Port.: Anginova; Chimar; Rus.: Phlogenzym (Флогэнзим); Wobe-Mugos E (Вобэ-Мугос Е); Wobenzym (Вобэнзим); Spain: Bristaciclina Dental; Dertrase; Dosil Enzimatico; Doxiten Enzimatico; Kanapomada; Naso Pekamin; Oxidermiol Enzima†; Quimodril; USA: Allanderm-T; Dermuspray; Granulderm; Granulex; GranuMed; Xenaderm; Venez.: Phlogenzym; Wobenzym N.
Published May 08, 2019.