Trypan Blue

(BAN, rINN)

💊 Chemical information

CI Direct Blue 14; Colour Index No. 23850; Trypanum Caeruleum. Tetrasodium 3,3′-[(3,3′-dimethylbiphenyl-4,4′-diyl)bisazo]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate].
Chemical formula: C34H24N6Na4O14S4 = 960.8.
CAS — 72-57-1.

💊 Profile

Trypan blue solutions are used as stains in microscopy and for visualisation of various tissues as an aid to ophthalmic surgery.
1. Werner L, et al. Permanent blue discoloration of a hydrogel intraocular lens by intraoperative trypan blue. J Cataract Refract Surg 2002; 28: 1279–86
2. Haritoglou C, et al. Functional outcome after trypan blue-assisted vitrectomy for macular pucker: a prospective, randomized, comparative trial. Am J Ophthalmol 2004; 138: 1–5
3. Gouws P, et al. Cystoid macular oedema with trypan blue use. Br J Ophthalmol 2004; 88: 1348–9
4. Lee KL, et al. A comparison of outcomes after indocyanine green and trypan blue assisted internal limiting membrane peeling during macular hole surgery. Br J Ophthalmol 2005; 89: 420–4
5. Healey PR, Crowston JG. Trypan blue identifies antimetabolite treatment area in trabeculectomy. Br J Ophthalmol 2005; 89: 1152–6
6. Roos JC, Kerr Muir MG. Use of trypan blue for penetrating keratoplasty. J Cataract Refract Surg 2005; 31: 1867–9.

💊 Preparations

Proprietary Preparations

Ital.: Oftalblu; Neth.: MembraneBlue; VisionBlue; USA: VisionBlue. Multi-ingredient: Fr.: Parkipan†.
Published May 08, 2019.