Troxerutin

(BAN, rINN)
Troxerutin Chemical formula
Synonyms: THR; Trihydroxyethylrutoside; Trioxyethylrutin; Trokserutiini; Trokserutyna; Troxerutina; Troxérutine; Troxerutinum. 3′,4′,7Tris[O-(2-hydroxyethyl)]rutin; 5-Hydroxy-7-(2-hydroxyethoxy)2-[3,4-bis(2-hydroxyethoxy)phenyl]-4-oxo-4H-chromen-3-yl rutinoside.
Cyrillic synonym: Троксерутин.

💊 Chemical information

Chemical formula: C33H42O19 = 742.7.
CAS — 7085-55-4.
ATC — C05CA04.
ATC Vet — QC05CA04.

Description.

Troxerutin is the principal component of oxerutins, above.

Pharmacopoeias.

In Eur..

Ph. Eur. 6.2

(Troxerutin). A yellowish-green, hygroscopic, crystalline powder. Freely soluble in water; slightly soluble in alcohol; practically insoluble in dichloromethane. Store in airtight containers. Protect from light.

💊 Profile

Flavonoids are naturally occurring antoxidants that are widely distributed in plants. Preparations containing natural or semisynthetic flavonoids are thought to improve capillary function by reducing abnormal leakage. They have been given to relieve capillary impairment and venous insufficiency of the lower limbs, and for haemorrhoids. It has been suggested that flavonoids present in some foods, such as fruit, vegetables, tea, and red wine may protect against the development of atherosclerosis.
1. Knekt P, et al. Flavonoid intake and coronary mortality in Finland: a cohort study. BMJ 1996; 312: 478–81
2. Hertog MGL, et al. Antioxidant flavonols and coronary heart disease risk. Lancet 1997; 349: 699
3. Youdim KA, et al. Dietary flavonoids as potential neuroprotectants. Biol Chem 2002; 383: 503–19
4. Lopez-Lazaro M. Flavonoids as anticancer agents: structure-activity relationship study. Curr Med Chem Anti-Canc Agents 2002; 2: 691–714
5. Lyseng-Williamson KA, Perry CM. Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids. Drugs 2003; 63: 71–100
6. Alonso-Coello P, et al. Meta-analysis of flavonoids for the treatment of haemorrhoids. Br J Surg 2006; 93: 909–20
7. Cermak R. Effect of dietary flavonoids on pathways involved in drug metabolism. Expert Opin Drug Metab Toxicol 2008; 4: 17–35.

Interactions.

For a report of quercetin increasing the bioavailability and concentration of ciclosporin.

💊 Preparations

Proprietary Preparations

Arg.: Flebon; Flebotropin; Flerox†; Jatamansin†; Rutilina; Terbenol; Venoruton; Venosmil; Austral.: Paroven; Austria: Venoruton; Belg.: Docrutosi; Veinamitol; Ven-Detrex; Venoruton; Braz.: Daflon; Flavonid; Venoruton; Chile: Flebopex; Insuven; Venoruton; Cz.: Cilkanol; Venoruton; Denm.: Venoruton; Fr.: Daflon; Diamoril†; Dio; Diosmil†; Diovenor; Endium; Flavan; Flebosmil; Intercyton; Mediveine; Preparation H Veinotonic; Relvene; Rheoflux; Titanoral; Veinamitol; Veineva; Venirene; Ger.: Drisi-Ven†; Posorutin; Rutinion; Tovene; Troxeven; Vastribil†; Veno SL; Venoruton; Venotrulan Trox; Gr.: Radiavit; Rioven†; Venoruton; Hong Kong: Venoruton†; Hung.: Veinamitol†; Venoruton; India: Venusmin; Indon.: Ardium; Venaron; Israel: Veinamitol†; Venoruton; Vridol†; Ital.: Alven; Arvenum; Diosven; Doven; Pericel; Venolen; Venoruton; Venosmine; Mex.: Sies; Teboven; Neth.: Venoruton; NZ: Paroven; Philipp.: Varemoid; Venoruton; Pol.: Otrex; Phlebodia; Posorutin; Rutinoven; Rutoven; Troxeratio; Venolan; Venoruton; Venotrex; Port.: Arvenum; Hepacalmina; Muralion; Venex; Veno V; Venoruton; Venosmil; Veroven; Rus.: Phlebodia (Флебодиа); Troxevazin (Троксевазин); Venoruton (Венорутон); S.Afr.: Paroven; Spain: Esberiven; Pentovena†; Venolep; Venoruton; Venosmil; Switz.: Hemerven; Neorutin†; Pur-Rutin; Venoruton; Venutabs; Thai.: Flavon; Heteroid; Venoruton; Turk.: Daflon; Venoruton; UK: Paroven; USA: Citro-Flav; Limbrel; Venez.: Diovenor; Flavol; Hyflon; Verutil. Multi-ingredient: Arg.: Accesum; Ajomast Circulatorio†; CVP B1 B6 B12†; CVP Duo; CVP Flebo; CVP Forte; Cyclo 3; Daflon; Dipemina; Diroseal; Epiteliol-C; Esberiven; Escina Forte; Escina Omega; Esculeol P; Exail; Fiblast; Flebitol; Flebotropin†; GB 100; HDG; Kacerutin; Microsuy; Mimixin; Phlogenzym†; Terbenol Duo; Troxeven†; Tubarine; Ulcevarin†; Varisedan; Vefluxan†; Venart; Venidium; Veraldid; Vitamina C-Complex; VNS 45; Austral.: B-Complex Threshold; Beta A-C; Bio C; Bio-C Complex; Bioglan Cirflo†; Bioglan Mega C; Bioglan Super Cal C; Bioglan The Blue One; Bioglan Zellulean with Escin; Bioglan Zn-A-C; C Supa + Bioflavonoids†; Cold & Flu Tablets Non Drowsy; Devils Claw Plus; Extralife Leg-Care; Eye Health Herbal Plus Formula 4; Flavonoid Complex; Flavons; For Peripheral Circulation Herbal Plus Formula 5; Gentle C with Bioflavonoids†; Lifesystem Herbal Formula 6 For Peripheral Circulation†; Lifesystem Herbal Plus Formula 5 Eye Relief†; Macro C†; Proflo†; Rubus Complex†; Super Cal-C Bio; Sustained Release C; Austria: Calcipot C; Cebion plus Rutin; Daflon; Helopyrin; Iroviton Multivitamin; Phlebodril; Phlogenzym; Ruticalzon; Rutiscorbin†; Rutiviscal; Rutozym; Sklerovitol; Tetesept; Traumazym; Trimedil; Venotop; Vit-C-Lutsch; Waldheim Influvidon; Wobenzym; Belg.: Daflon; Mictasol-P; Braz.: Castanha de India Composta†; Dactil OB; Daflon 500; Diosmin; Flebotrat†; Gingilone; Gripen; Hemodotti; Hemorroidex†; Manolio†; Mirorroidin†; Novarrutina; Panvitrop; Trimedal; Varicoss; Varizol†; Venaflon; Venalot; Venocur Triplex; Venovaz; Canad.: Ultra Quercitin; Chile: Daflon 500; Dipemina; Diroseal; Duo-CVP; Hemoplex†; Phyto Corrective Gel; Primacy Phyto +†; Venartel; Vesnidan; Cz.: Anavenol; Ascorutin; Cyclo 3 Fort; Detralex; Ginkor Fort; Phlogenzym; Wobenzym; Denm.: Capiven; Fr.: Avene Antirougeurs; Bicirkan; Cemaflavone; Cirkan; Cyclo 3 Fort; Diroseal; Esberiven Fort; Gel a l’Acetotartrate d’Alumine Defresne†; Ginkor; Ginkor Fort; Ophtadil†; Rheobral; Vascocitrol; Veliten; Venyl†; Vivene†; Ger.: Antihypertonicum S; Calcium-Rutinion†; Cycloven Forte N; Emocrat forte†; Enzym-Wied†; Essaven N†; Essaven ultra†; Eukalisan N; Fagorutin Buchweizen; Fagorutin Rosskastanien-Balsam N; Intradermi; Lindigoa S†; Movicard; Perivar†; Phlebodril; Phlogenzym; Posti N†; Ruticalzon VC†; Tornix; Vaso-EBion; Venalot; Venalot N†; Veno-Tebonin N†; Vitosal†; Wobenzym N; Gr.: Abanifan; Antican; Bioflevin; Cidoston; Cyclo 3 Forte; Daflon; Diosper; Dispedrol; Flavon†; Flevion; Flevostol; Gamophen; Mecaton; Noxarel; Oflazet; Pelethrocin; Roxydral; Smudal; Venosman†; Hong Kong: Daflon; Ginkor Fort; Hemo Rid; Poly C†; Quali-Flon; Hung.: Detralex; Ginkor Fort; Phlogenzym; Rutascorbin; India: Cadisper C; CKP; CVP; Gynae-CVP; Kalpastic; Styptocid; Styptocip†; Indon.: Ambeven Plus; Ciflon; Papaven; Vedium; Israel: Opti-safe; Ital.: Angioton; Capill Venogel; Daflon 500; Dermoangiopan†; Digifar†; Diosmina Complex; Emortrofine; Facosmina; Flebil Plus; Flebo-Si; Flebofort; Flebolider; Fleboside; Ginkoftal; Levital Plus; Neomyrt Plus; Pulsalux; RepaVen†; Rutisan CE†; Traumal†; Varicofit; Venactive†; Venodin; Venoton; Voltatrauma; Malaysia: Daflon 500; Ginkor Fort; Hemorid; Nat-C; Mex.: Cal-Rutina; Daflon; Elatec; Fabroven; Flavit; Phlogenzym; Variton; Venalot; Wobenzym; NZ: Botanica Hayfever; Philipp.: Daflon; Pol.: Alliorut; Anavenol; Ascorutical; Biovision; Cerutin; Cyclo 3 Fort; Detralex; Kelicardina; Pelethrocin; Rutinacea; Rutinoscorbin; Rutinoscorbin Plus; Rutokal C; Rutovit C; Sapoven AT; Sapoven T; Scorbolamid; Troxescorbin; Venacorn; Venescin; Port.: Actilam; Cegripe; Cyclo 3; Daflon; Rimanal; Rutinice Fortissimo; Rus.: Anavenol (Анавенол); AntigrippinANVI (Антигриппин-АНВИ); Ascorutical (Аскорутикаль); Cyclo 3 Fort (Цикло-3 Форт); Detralex (Детралекс); Ginkor Fort (Гинкор Форт); Ginkor Gel (Гинкор Гель); Indovasin (Индовазин); Phlogenzym (Флогэнзим); Prophylactin C (Профилактин С); Venolife (Венолайф); Wobenzym (Вобэнзим); S.Afr.: Essaven†; Singapore: Cyclo 3 Fort; Daflon 500; Diosper; Poly C; Spain: Caprofides Hemostatico; Daflon 500; Epistaxol; Fabroven; Flebeside†; Gingilone; Nasopomada; Switz.: Biovital Ginseng; Daflon 500; Demoven N; Flavovenyl; Lapidar 4; Phlebodril N; Video-Net†; Thai.: Biocalron; Cyclo 3 Fort; Daflon; Dafomin; Essaven; Ginkor Fort; Heroid; Nat-C Medicrafts; Siduol; USA: Amino-Opti-C; C Factors "1000" Plus; Cholinoid; Citrus-flav C; Ester-C Plus; Ester-C Plus Multi-Mineral; Flavons; Lipoflavonoid; Pan C; Peridin-C; Proflavanol; Pycnogenol Plus; Span C; Venez.: Daflon; Disolina; Dremo-K†; Phlogenzym; Wobenzym N.
Published May 08, 2019.