Tin-protoporphyrin

(rINN)

Chemical information

Protoporfirina-Estaño; (Sn)-protoporphyrin.

Profile

Tin-protoporphyrin and the related compound tin-mesoporphyrin are metalloporphyrins which inhibit haem oxygenase, an enzyme involved in the breakdown of haem to bile pigments. They have been investigated as inhibitors of bilirubin production in hyperbilirubinaemia of various causes, and have been tried in porphyria.
1. Valaes T, et al. Control of hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns using an inhibitor of bilirubin production, Sn-mesoporphyrin. Abstract: Pediatrics 1998; 101: 915. Full version: http://pediatrics.aappublications.org/cgi/ content/full/101/5/e1 (accessed 09/07/04
2. Martinez JC, et al. Control of severe hyperbilirubinemia in fullterm newborns with the inhibitor of bilirubin production Snmesoporphyrin. Pediatrics 1999; 103: 1–5
3. Kappas A, et al. A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns. Pediatrics 2001; 108: 25–30
4. Kappas A, et al. Sn-mesoporphyrin interdiction of severe hyperbilirubinemia in Jehovah’s Witness newborns as an alternative to exchange transfusion. Pediatrics 2001; 108: 1374–7
5. Kappas A. A method for interdicting the development of severe jaundice in newborns by inhibiting the production of bilirubin. Pediatrics 2004; 113: 119–23
6. Drummond GS, Kappas A. Chemoprevention of severe neonatal hyperbilirubinemia. Semin Perinatol 2004; 28: 365–8
7. Dennery PA. Metalloporphyrins for the treatment of neonatal jaundice. Curr Opin Pediatr 2005; 17: 167–9.
Published May 08, 2019.