Tilarginine

(rINN)
Tilarginine Chemical formula
Synonyms: BW-546C88; 546C88; L-NMMA; Targinina; Targinine (BAN); Targininum; Tilarginina; Tilargininum. N-Methyl
Cyrillic synonym: Таргинин.

Chemical information

Chemical formula: C7H16N4O2 = 188.2.
CAS — 17035-90-4.

Profile

Tilarginine is a nitric oxide synthase inhibitor under investigation in the treatment of cardiogenic shock, although results have been disappointing. It has also been tried in septic shock but appears to have been associated with increased mortality. It has also been investigated in migraine.
1. Lassen LH, et al. The effect of nitric oxide synthase inhibition on histamine induced headache and arterial dilatation in migraineurs. Cephalalgia 2003; 23: 877–86
2. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med 2004; 32: 1–12
3. Watson D, et al. Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, doubleblind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med 2004; 32: 13–20
4. Lopez A, et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 2004; 32: 21–30
5. Alexander JH, et al. TRIUMPH Investigators. Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. JAMA 2007; 297: 1657–66.
Published May 08, 2019.