Thymus Hormones

(USAN, rINN)

💊 Chemical information

Timo, hormonas del.
CAS — 69558-55-0 (thymopentin); 60529-76-2 (thymopoietin); 63340-72-7 (thymic humoral factor).

💊 Profile

The thymus gland controls the development of T-lymphocytes and thereby plays a central role in cell-mediated immunity and the regulation of immune responses. Several polypeptides characterised in the thymus or serum are able to induce lymphocyte differentiation in vitro and in vivo. They include: thymosin fraction 5, a crude thymus gland extract; thymalfasin; thymosin beta 4; thymic humoral factor (THF), isolated from crude thymic extract dialysate; nonathymulin (thymulin, serum thymic factor, Facteur Thymique Serique, FTS), a synthetic nonapeptide; thymomodulin, a partially purified extract from calf thymus; thymogene A, extracted from calf thymus; thymopoietin, a polypeptide of known amino acid sequence; thymopentin (thymopoietin pentapeptide, TP-5), a fragment of thymopoietin with 5 amino acids; and thymostimulin (TP-1), extracted from calf thymus. Various preparations, including crude extracts from calf thymus gland, thymomodulin, thymopentin, and thymostimulin have been tried as immunomodulators in numerous conditions including rheumatoid arthritis, diabetes mellitus, immunodeficiency disorders, skin disorders, malignant neoplasms, and some infections.
1. Huff T, et al. β-Thymosins, small acidic peptides with multiple functions. Int J Biochem Cell Biol 2001; 33: 205–20
2. Hannappel E, Huff T. The thymosins—prothymosin alpha, parathymosin, and beta-thymosins: structure and function. Vitam Horm 2003; 66: 257–96
3. Goldstein AL, Badamchian M. Thymosins: chemistry and biological properties in health and disease. Expert Opin Biol Ther 2004; 4: 559–73
4. Chen C, et al. Roles of thymosins in cancers and other organ systems. World J Surg 2005; 29: 264–70.

💊 Preparations

Proprietary Preparations

Arg.: Leucotrofina; Austral.: Thymunes; Braz.: Leucogen; Cz.: TP-1†; Ger.: Thym-Uvocal; Thymo-Glanduretten†; Thymoject; Thymophysin; Thymowied†; Ital.: Sintomodulina. Multi-ingredient: Austria: Wobe-Mugos; Cz.: Wobe-Mugos†.
Published May 08, 2019.