Tesmilifene Hydrochloride

(USAN, rINNM)
Tesmilifene Hydrochloride Chemical formula
Synonyms: BMS-217380-01; BMY-33419; DPPE; Hidrocloruro de tesmilifeno; Tesmilifène, Chlorhydrate de; Tesmilifeni Hydrochloridum. 2-[( thyl-2-[4-(phenylmethyl)phenoxy]-ethanamine hydrochloride.
Cyrillic synonym: Тезмилифена Гидрохлорид.

Chemical information

Chemical formula: C19H25NO,HCl = 319.9.
CAS — 98774-23-3 (tesmilifene); 92981-78-7 (tesmilifene hydrochloride).

Profile

Tesmilifene hydrochloride is an intracellular histamine antagonist that appears to augment the antineoplastic activity of drugs such as the anthracyclines and taxanes. It is under investigation for the treatment of various cancers, including hormone-refractory cancer of the prostate and gastric and hepatic cancers.
1. Reyno L, et al. Phase III study of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (BMS-217380-01) combined with doxorubicin versus doxorubicin alone in metastatic/recurrent breast cancer: National Cancer Institute of Canada Clinical Trials Group Study MA19. J Clin Oncol 2004; 22: 269–76
2. Raghavan D, et al. Phase II trial of tesmilifene plus mitoxantrone and prednisone for hormone refractory prostate cancer: high subjective and objective response in patients with symptomatic metastases. J Urol (Baltimore) 2005; 174: 1808–13.
Published May 08, 2019.