Tartaric Acid

(rINN)

💊 Chemical information

Acide tartrique; Acidum tartaricum; Borko˝sav; E334; E353 Tartárico, ácido; Tartarik Asit; Tartrique (Acide); Viinihappo; Vinsyra; Vyno ru _ gštis; Weinsäure. (+)Dihydroxybutane-1,4-dioic acid.
Chemical formula: C4H6O6 = 150.1.
CAS — 87-69-4; 526-83-0.

Pharmacopoeias.

In Eur. and Jpn. Also in USNF.

Ph. Eur. 6.2

(Tartaric Acid). A white or almost white, crystalline powder or colourless crystals. Very soluble in water; freely soluble in alcohol.

USNF 26

(Tartaric Acid). Colourless or translucent crystals or a white, fine to granular, crystalline powder. Is odourless. Soluble 1 in 0.8 of water, 1 in 0.5 of boiling water, 1 in 3 of alcohol, 1 in 250 of ether, and 1 in 1.7 of methyl alcohol.

💊 Adverse Effects

Strong solutions of tartaric acid are mildly irritant and if ingested undiluted may cause violent vomiting and diarrhoea, abdominal pain, and thirst. Cardiovascular collapse or acute renal failure may follow.

💊 Pharmacokinetics

Tartaric acid is absorbed from the gastrointestinal tract but up to 80% of an ingested dose is probably destroyed by micro-organisms in the lumen of the intestine before absorption occurs. Absorbed tartaric acid is excreted unchanged in the urine.

💊 Uses and Administration

Tartaric acid is used in the preparation of effervescent powders, granules, and tablets, as an ingredient of cooling drinks, and as a saline purgative. If not neutralised, it must be taken well diluted. Tartaric acid or metatartaric acid are used in wine-making as deacidifying agents to assist in the removal of excess malic acid by forming an insoluble double salt with calcium carbonate.

💊 Preparations

Proprietary Preparations

Multi-ingredient: Austral.: Citralite; Citravescent; Dexsal; Salvital; Ural; Uricalm†; Austria: Duplotrast Weinsaure; Helo-acid; Lactolavol; Belg.: Zoru†; Canad.: E-Z-Gas II†; Chile: Frunalia; Frutasal Knop; Uroknop; Fr.: Dermacide; Zeniac LP Fort†; Ger.: Retterspitz Ausserlich; Retterspitz Innerlich; India: Urisoda; Ital.: Antimicotica Solforata; Geffer; Magnesia Effervescente Sella; Malaysia: Citravescent†; Ezee; Ural; NZ: Ural; Port.: Safrux; Thiospot; S.Afr.: Adco-Sodasol; Alkafizz; Citro-Soda; Quatro-Soda†; Uri-Alk; Spain: Citinoides; Hectonona; Salcedol; Sales de Frutas P G; Sales Fruta Mag Viviar; Salmagne; Switz.: Siesta-1; Turk.: Enhos; Purgyl; UK: Jaaps Health Salt; USA: Baros.
Published May 08, 2019.