Stramonium

(USAN, rINNM)

💊 Chemical information

Datura; Durmanový list (stramonium leaf); Durnaropiu lapai leaf); Inferno; Jamestown Weed; Jimson Weed; Maszlaglevél niumblad (stramonium leaf); Thornapple.
ATC Vet — QR03BB03.

Pharmacopoeias.

Eur. includes a monograph for Stramonium Leaf and Prepared Stramonium.

Ph. Eur. 6.2 (Stramonium Leaf; Stramonii Folium). It consists of the dried leaf or the dried leaf, flowering tops and occasionally fruit-bearing tops of Datura stramonium and its varieties. It contains not less than 0.25% of total alkaloids, calculated as hyoscyamine. The alkaloids consist mainly of hyoscyamine with varying proportions of hyoscine. It has an unpleasant odour. Protect from light and moisture. The BP 2008 directs that when stramonium leaf or powdered stramonium leaf is prescribed, prepared stramonium shall be dispensed.

Ph. Eur. 6.2 (Stramonium, Prepared; Stramonii Pulvis Normatus). It is stramonium leaf powder adjusted to contain 0.23 to 0.27% of total alkaloids, calculated as hyoscyamine. Store in airtight containers. Protect from light.

💊 Adverse Effects, Treatment, and Precautions

As for Atropine Sulfate.

Abuse.

Some reports1-5 of poisoning after abuse of Datura stramonium or its preparations.
1. Gowdy JM. Stramonium intoxication: review of symptomatology in 212 cases. JAMA 1972; 221: 585–7
2. Shervette RE, et al. Jimson “Loco” weed abuse in adolescents. Pediatrics 1979; 63: 520–3
3. Anonymous. Jimson weed poisoning—Texas, New York, and California, 1994. MMWR 1995; 44: 41–4
4. Salen P, et al. Effect of physostigmine and gastric lavage in a Datura stramonium-induced anticholinergic poisoning epidemic. Am J Emerg Med 2003; 21: 316–17
5. Boumba VA, et al. Fatal poisoning from ingestion of Datura stramonium seeds. Vet Hum Toxicol 2004; 46: 81–2.

Effects on the eyes.

Anisocoria (unequal dilatation of the pupils) developed after accidental entry of a piece of jimson weed (Datura stramonium) into a patient’s eye while gardening.1
1. Savitt DL, et al. Anisocoria from Jimsonweed. JAMA 1986; 255: 1439–40.

💊 Uses and Administration

Stramonium has the actions of atropine. It has been given with other drugs in oral and rectal dosage forms for respiratory-tract disorders. It has also been smoked in cigarettes or burnt in powders and the fumes inhaled but the irritation produced by the fumes may aggravate bronchitis.

Homoeopathy.

Stramonium has been used in homoeopathic medicines under the following names: Datura stramonium; Stram.

💊 Preparations

Proprietary Preparations

Multi-ingredient: Austral.: Potassium Iodide and Stramonium Compound†; Braz.: Asmatiron†; Expectol†; Teutoss†.
Published May 08, 2019.