Star Anise

(USAN, rINNM)

💊 Chemical information

Anís Estrellado; Anis Étoilé; Anisi stellati fructus; Anisum Badium; Anisum Stellatum; Badiana; Badiane; Badiane de Chine; Badyáníkový plod; Chinese Star Anise; Csillagánizs; Owoc anyz ugwiaździstego; Star Anise Fruit; Sternanis; Stjärnanis; Tähtianis; Žvaigždanyžiu vaisiai.

Pharmacopoeias.

In Chin. and Eur..

Ph. Eur. 6.2

(Star Anise; Anisi Stellati Fructus). The dried composite fruit of Illicium verum, containing not less than 7% v/w of essential oil with reference to the anhydrous drug and a minimum 86.0% of trans-anethole in the essential oil. Protect from light.

💊 Profile

The fruit of star anise, Illicium verum (Illiciaceae), is used as an expectorant for catarrh and as a gastrointestinal antispasmodic. It is used with thyme in herbal preparations for colds and upper respiratory-tract disorders. It is also used as a culinary spice. Star anise is the source of star anise oil (below). It is also the source of shikimic acid, which is used in the production of the anti-influenza drug oseltamivir. Adulteration of star anise with Japanese star anise (shikimi fruits; I. anisatum) has been responsible for a number of cases of neurotoxicity (see below). Import restrictions have been implemented in the EU. The problem is further complicated because the name I. anisatum has been applied to I. verum.

Adverse effects.

Neurotoxicity has been associated with the use of star anise infusions in infants.1-3 The toxicity is attributed to adulteration or contamination of Chinese star anise (Illicium verum) with Japanese star anise (I. anisatum) which contains toxic sesquiterpene lactones such as anisatin.
1. Garzo Fernandez C, et al. Casos de enfermedad de sintomatología neurológica asociados al consumo de anís estrellado empleado como carminativo. An Esp Pediatr 2002; 57: 290–4
2. Minodier P, et al. Intoxication aiguë par la badiane chez Le nourrisson. Arch Pediatr 2003; 10: 619–21
3. Ize-Ludlow D, et al. Neurotoxicities in infants seen with the consumption of star anise tea. Abstract: Pediatrics 2004; 114: 1330. Full version: http://pediatrics.aappublications.org/cgi/content/ full/114/5/e653 (accessed 04/05/06)

💊 Preparations

Proprietary Preparations

Multi-ingredient: Braz.: Dorveran†; Ductoveran; Elixir 914†; Cz.: Naturland Grosser Swedenbitter†; Ital.: Relaxcol; Spain: Digestovital†; Switz.: Tisane laxative; Tisane pectorale et antitussive; Venez.: Atrobel; Cloverin†; Ervossil.
Published May 08, 2019.