Sivelestat Sodium

Synonyms: Natrii Sivelestatum; Sivelestat sódico; Sivélestat Sodique.
Cyrillic synonym: Натрий Сивелестат.

💊 Chemical information

Chemical formula: C20H21N2NaO7S,4H2O = 528.5.
CAS — 201677-61-4.

💊 Profile

Sivelestat is an elastase inhibitor that primarily inhibits neutrophil elastase. It is given by intravenous infusion as the sodium salt in the treatment of acute lung injury associated with systemic inflammatory response syndrome. However, a large study in patients with acute lung injury did not find it of benefit.
1. Zeiher BG, et al. Neutrophil elastase and acute lung injury: prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics. Crit Care Med 2002; 30 (suppl): S281–S287
2. Zeiher BG, et al. Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. Crit Care Med 2004; 32: 1695–1702.

💊 Preparations

Proprietary Preparations

Jpn: Elaspol.
Published May 08, 2019.