Sincalide

(BAN, USAN, rINN)
Synonyms: CCK-OP; Sincalida; Sincalidum; Sinkalid; Sinkalidi; SQ-19844. De1-(5-oxo
Cyrillic synonym: Синкалид.

💊 Chemical information

Chemical formula: C49H62N10O16S3 = 1143.3.
CAS — 25126-32-3.
ATC — V04CC03.
ATC Vet — QV04CC03.

Pharmacopoeias.

US includes Sincalide for Injection.

💊 Adverse Effects

Sincalide stimulates gallbladder contraction and gastrointestinal muscle and may give rise to abdominal discomfort. Dizziness, nausea, and flushing may also occur.

💊 Uses and Administration

Sincalide is the synthetic C-terminal octapeptide of cholecystokinin and when given by intravenous injection it stimulates gallbladder contraction; it also stimulates intestinal muscle. Sincalide is used for testing gallbladder function and as an adjunct to cholecystography. It is usually given in doses of 20 nanograms/kg by intravenous injection over 30 to 60 seconds. It is also used as a diagnostic agent, often with secretin, for testing the functional capacity of the pancreas; this test generally requires duodenal intubation of the patient and examination of duodenal aspirate. A suggested procedure is to give a 1-hour intravenous infusion of secretin, and 30 minutes after starting this infusion, to start a separate infusion of sincalide 20 nanograms/kg over a 30-minute period. A dose of 40 nanograms/kg may be given to accelerate the transit time of a barium meal through the small bowel; it should be given after the barium meal has passed the proximal jejunum.

💊 Preparations

USP 31: Sincalide for Injection.

Proprietary Preparations

Canad.: Kinevac†; USA: Kinevac.
Published May 08, 2019.