Silver Protein

(rINN)

💊 Chemical information

Albumosesilber; Argent, protéinate d’; Argentoproteinum; Argentum proteicum; Argentum Proteinicum; Hopeaproteiini; Plata, proteína de; Protargolum; Proteinato de Plata; Proteinato de Prata; Silverprotein; Srebra proteinicum; Strong Protargin; Strong Protein Silver; Strong Silver Protein.
CAS — 9007-35-6 (colloidal silver); 9015-51-4 (silver protein).

Pharmacopoeias.

In It., Jpn, and Viet. Eur. includes Silver, Colloidal, for External Use.

Ph. Eur. 6.2

(Silver, Colloidal, for External Use; Argentum Colloidale ad Usum Externum). It is colloidal metallic silver, containing protein. It contains 70.0 to 80.0% of Ag, calculated with reference to the dried substance. Green or bluish-black, metallic, hygroscopic, shiny flakes or powder. Freely soluble or soluble in water; practically insoluble in alcohol and in dichloromethane. Store in airtight containers.

💊 Profile

Silver protein solutions have antibacterial properties, due to the presence of low concentrations of ionised silver, and have been used as eye drops and for application to mucous membranes. The mild form of silver protein is considered to be less irritating, but less active. Colloidal silver, which is also a preparation of silver in combination with protein, has also been used topically for its antibacterial activity.

Homoeopathy.

Silver protein has been used in homoeopathic medicines under the following names: Argentum colloidale.

Adverse effects.

Irreversible neurotoxicity associated with the daily ingestion of a home-made colloidal silver drink for 4 months developed in an elderly patient.1 He presented with myoclonic status epilepticus, then entered into a prolonged coma, and eventually died of pneumonia some months later. On admission, high levels of silver were found in the plasma, erythrocytes, and CSF, and at autopsy there was evidence of selective silver accumulation in the brain. As of October 2007, four reports of silver toxicity in patients ingesting home-made products, likewise prepared using a colloidal silver generator, had also been received by the Australian Adverse Drug Reactions Advisory Committee (ADRAC);2 one patient also applied it topically after shaving. All patients had high plasma-silver concentrations and developed skin discoloration; some also had systemic symptoms including hepatotoxicity, cardiomyopathy, amnesia, and incoherent speech. For argyria after prolonged use of nasal drops containing silver protein see under Silver, above.
1. Mirsattari SM, et al. Myoclonic status epilepticus following repeated oral ingestion of colloidal silver. Neurology 2004; 62: 1408–10
2. Adverse Drug Reactions Advisory Committee (ADRAC). Dangers associated with chronic ingestion of colloidal silver. Aust Adverse Drug React Bull 2007; 26: 19. Also available at: http:// www.tga.gov.au/adr/aadrb/aadr0710.pdf (accessed 24/06/08)

💊 Preparations

Proprietary Preparations

Braz.: Argirol; Fr.: Stillargol; Ger.: Rhinoguttae Argenti diacetylotannici proteinici; Rhinoguttae pro Infantibus N. Multi-ingredient: Austria: Coldargan; Belg.: Argyrophedrine; Ger.: Gastrarctin N; Hung.: Coldargan; Ital.: Argirofedrina†; Argisone; Argotone; Arscolloid; Bio-Arscolloid; Corti-Arscolloid; Rinantipiol†; Rinofomentil†; Port.: Naso-Calma†.
Published May 08, 2019.