Sesame Oil

(rINN)

💊 Chemical information

Aceite de Ajonjoli; Benne Oil; Gingelly Oil; Oleum Sesami; Refined Sesame Oil; Seesamiöljy; Sésame, huile de; Sesami oleum; Sésamo, aceite de; Sesamolja; Sezamový olej; Sezamu aliejus; Szezámolaj; Teel Oil.
CAS — 8008-74-0.

Pharmacopoeias.

In Chin., Eur., and Jpn. Also in USNF.

Ph. Eur. 6.2

(Sesame Oil, Refined; Sesami Oleum Raffinatum). The fatty oil obtained from the ripe seeds of Sesamum indicum by expression or extraction and subsequent refining. It may contain a suitable antoxidant. It is a clear, light yellow, almost colourless liquid. It solidifies to a soft mass at about −4°. Practically insoluble in alcohol; miscible with petroleum spirit. Store in well-filled, airtight containers. Protect from light. Refined sesame oil for use in the manufacture of parenteral dosage forms should be stored under an inert gas in airtight containers.

USNF 26

(Sesame Oil). The refined fixed oil obtained from the seed of one or more cultivated varieties of Sesamum indicum (Pedaliaceae). It may contain suitable antoxidants. A pale yellow, practically odourless, oily liquid. Slightly soluble in alcohol; miscible with carbon disulfide, with chloroform, with ether, and with petroleum spirit. Store in airtight containers at a temperature not exceeding 40°. Protect from light.

💊 Profile

Sesame oil has been used in the preparation of liniments, plasters, ointments, and soaps. Because it is relatively stable, it is a useful solvent and vehicle for parenteral products. Hypersensitivity reactions have been seen.

Adverse effects.

References to hypersensitivity reactions1-7 associated with sesame, and subcutaneous nodules8 after injection of the oil.
1. Kanny G, et al. Sesame seed and sesame seed oil contain masked allergens of growing importance. Allergy 1996; 51: 952–7
2. Stern A, Wuthrich B. Non-IgE-mediated anaphylaxis to sesame. Allergy 1998; 53: 325–6
3. Pecquet C, et al. Immediate hypersensitivity to sesame in foods and cosmetics. Contact Dermatitis 1998; 39: 313
4. Asero R, et al. A case of sesame seed-induced anaphylaxis. Allergy 1999; 54: 526–7
5. Dalal I, et al. The pattern of sesame sensitivity among infants and children. Pediatr Allergy Immunol 2003; 14: 312–16
6. Agne PS, et al. Sesame seed allergy in children. Allerg Immunol (Paris) 2004; 36: 300–305
7. Gangur V, et al. Sesame allergy: a growing food allergy of global proportions? Ann Allergy Asthma Immunol 2005; 95: 4–11
8. Darsow U, et al. Subcutaneous oleomas induced by self-injection of sesame seed oil for muscle augmentation. J Am Acad Dermatol 2000; 42: 292–4.

💊 Preparations

Proprietary Preparations

Canad.: Rhinaris Nozoil; UK: Noseeze. Multi-ingredient: Austral.: Snor-Away†; Ger.: GeloSitin; NZ: Snorenz; UK: Goodnight StopSnore; Snor-Away.
Published May 08, 2019.