Serrapeptase

(rINN)
Synonyms: Serrapeptasa; Serrapeptasum; Serrapeptidase; Serratia Extracellular Proteinase; Serratiopeptidase.
Cyrillic synonym: Серрапептаза.

💊 Chemical information

CAS — 37312-62-2; 95077-02-4.

Pharmacopoeias.

In Jpn.

💊 Profile

Serrapeptase is a proteolytic enzyme derived from Serratia spp. It has been taken orally for its supposed action in relieving inflammation and oedema associated with conditions such as trau ma, infection, respiratory-tract congestion, or chronic venous insufficiency, in usual doses of 5 to 10 mg (10 000 to 20 000 units) up to three times daily.
1. Tachibana M, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984; 3: 526–30
2. Paparella P, et al. Serratia peptidase and acute phase protein behavior following vaginal hysterectomy: results of a randomized double-blind, placebo-controlled trial. Curr Ther Res 1989; 45: 664–76
3. Shimizu H, et al. A case of serratiopeptidase-induced subepidermal bullous dermatosis. Br J Dermatol 1999; 141: 1139–40
4. Nakamura S, et al. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology 2003; 8: 316–20.

💊 Preparations

Proprietary Preparations

Arg.: Danzen; Chile: Damizen; Fr.: Dazen; Ger.: Aniflazym; Gr.: Brasan; Enziflur†; Eze†; Lergan†; Verolin†; Hong Kong: Danzen; Unizen; India: Bidanzen; Cipzen; Flanzen; Infladase; Kineto; Seraim; Serato-M; Ital.: Danzen; Jpn: Dasen; Malaysia: Danzen; Unizen; Mex.: Danzen; Port.: Aniflazime; Singapore: Danzen; Korzen†; Serrazyme; Sinsia; Unizen†; Thai.: Dailat; Danzen; Danzyme; Denzo; Medizyme†; Podase†; Rodase; Seramed; Serradase; Serrano; Serrao; Serrapep; Serrason; Serrin; Sumidin; Unizen. Multi-ingredient: India: Cipzen D; Cipzen N; Diser; Flanzen-D; Nimulid SP; Serato-M Forte†; Indon.: Dansera; Flavin; Nutriflam.
Published May 08, 2019.