Selfotel

(USAN, rINN)
Selfotel Chemical formula
Synonyms: CGS-19755; Selfotelum. cis-4-(Phosphonomethyl)pipecolic acid.
Cyrillic synonym: Сельфотел.

Chemical information

Chemical formula: C7H14NO5P = 223.2.
CAS — 110347-85-8.

Profile

Selfotel is an N-methyl-D-aspartate (NMDA) antagonist that has been investigated for use in ischaemic stroke and head trauma.
1. Davis SM, et al. Termination of acute stroke studies involving selfotel treatment. Lancet 1997; 349: 32
2. Yenari MA, et al. Dose escalation safety and tolerance study of the competitive NMDA antagonist selfotel (CGS 19755) in neurosurgery patients. Clin Neuropharmacol 1998; 21: 28–34
3. Stewart L, et al. First observations of the safety and tolerability of a competitive antagonist to the glutamate NMDA receptor (CGS 19755) in patients with severe head injury. J Neurotrauma 1999; 16: 843–50
4. Morris GF, et al. The Selfotel Investigators. Failure of the competitive N-methyl-D-aspartate antagonist selfotel (CGS 19755) in the treatment of severe head injury: results of two phase III clinical trials. J Neurosurg 1999; 91: 737–43
5. Davis SM, et al. Selfotel in acute ischemic stroke: possible neurotoxic effects of an NMDA antagonist. Stroke 2000; 31: 347–54.
Published May 08, 2019.