Schick Test

(rINN)

Chemical information

Prueba de Schick.

Pharmacopoeias.

Br. include standards for Schick test toxin and control.

BP 2008 (Schick Test Toxin). It is prepared from a toxigenic strain of Corynebacterium diphtheriae. It contains a suitable antimicrobial preservative. Store at 2° to 8°.

BP 2008 (Schick Control). It is Schick Test Toxin that has been heated at a temperature not lower than 70° and not higher than 85° for not less than 5 minutes. It is prepared from the same batch of Schick Test Toxin as that with which it is to be used. Store at 2° to 8°.

Profile

Intradermal injection of Schick test toxin has been used for the diagnosis of susceptibility to diphtheria and, more importantly, to detect patients who might experience an adverse reaction to diphtheria vaccines. Children up to the age of about 8 to 10 years rarely suffer from such reactions and therefore the Schick test is not usually performed in this age group. In older children and adults a Schick test was formerly used before the use of standard diphtheria vaccines. However, diphtheria vaccines for use in adults and adolescents are now formulated with lesser amounts of toxoid so Schick testing is unnecessary.
Published May 08, 2019.