💊 Chemical information

Bloodroot; Red Puccoon; Sanguinaria canadensis; Sanguinaris canadensis.

💊 Profile

Sanguinaria consists of the dried rhizome of Sanguinaria canadensis (Papaveraceae). Sanguinarine, an alkaloid extracted from sanguinaria, has been used as an antiplaque agent in toothpaste and mouthwash preparations. Sanguinaria was formerly used as an expectorant but fell into disuse because of its toxicity. Sanguinaria has also been classified by the FDA as a herb that is unsafe for use in foods, beverages, or drugs.


Sanguinaria has been used in homoeopathic medicines under the following names: Sanguinaria canadensis; Sang. ca. Sanguinarium nitrate has been used in homoeopathic medicines under the following names: Sanguinarinum Nitricum; Sang. nit.
1. Karlowsky JA. Bloodroot: Sanguinaria canadensis L. Can Pharm J 1991; 124: 260, 262–3, 267
2. Grenby TH. The use of sanguinarine in mouthwashes and toothpaste compared with some other antimicrobial agents. Br Dent J 1995; 178: 254–8
3. Tenenbaum H, et al. Effectiveness of a sanguinarine regimen after scaling and root planing. J Periodontol 1999; 70: 307–11.

Malignant neoplasms of the skin.

Self-treatment of basal cell carcinoma on the nasal tip by a 51-year-old man using a topical caustic preparation containing Sanguinaria canadensis has been reported.1 Although a similar caustic paste was originally used in the 1930s as part of Mohs’ micrographic surgery (MMS) for some types of skin cancer, the MMS technique in use today is more refined, and self-administration of caustic pastes containing sanguinaria for skin lesions is not recommended.
1. Affleck AG, Varma S. A case of do-it-yourself Mohs’ surgery using bloodroot obtained from the internet. Br J Dermatol 2007; 157: 1078–9.

💊 Preparations

Proprietary Preparations

Multi-ingredient: Arg.: Clematis III Oligoplex†; Austral.: Lexat†; Canad.: Bronchial Cough; Mielocol; Viadent†; Wampole Bronchial Cough Syrup†; Ital.: Dentosan Carie & Alito†; Eudent con Glysan†.
Published May 08, 2019.