Rubber

(BAN, USAN, rINN)

Chemical information

Caoutchouc; Caucho; India-Rubber.

Profile

Rubber consists of the prepared latex of Hevea brasiliensis and other species of Hevea (Euphorbiaceae). It is used as a component of many medical devices such as catheters, syringes, enema tips, ostomy bags, balloons, and surgical gloves. Hypersensitivity reactions have occurred after direct contact of skin and mucous membranes with rubber components of such products and also after indirect contact with preparations stored in or given by them; deaths have been reported. Reactions have been attributed either to protein components of the rubber or to additives such as preservatives or vulcanisation accelerators. For references to glove starch powder as a possible risk factor in the development of rubber latex allergy, see Glove Powder under Adverse Effects of Starch. Cross-sensitivity between rubber proteins and those of certain fruits, including bananas and chestnuts, has been reported.
1. Landwehr LP, Boguniewicz M. Current perspectives on latex allergy. J Pediatr 1996; 128: 305–12
2. Senst BL, Johnson RA. Latex allergy. Am J Health-Syst Pharm 1997; 54: 1071–5
3. Woods JA, et al. Natural rubber latex allergy: spectrum, diagnostic approach, and therapy. J Emerg Med 1997; 15: 71–85
4. Zaidi Z, et al. Latex allergy: a life-threatening complication. Hosp Med 1998; 59: 505–7
5. Smith CC. Risk of latex allergy from medication vial closures. Ann Pharmacother 1999; 33: 373–4
6. Wakelin SH, White IR. Natural rubber latex allergy. Clin Exp Dermatol 1999; 24: 245–8
7. Bowyer RVStL. Latex allergy: how to identify it and the people at risk. J Clin Nurs 1999; 8: 144–9
8. Levy DA, Leynadier F. Latex allergy: review of recent advances. Curr Allergy Rep 2001; 1: 32–8
9. Hamann CP, et al. Management of dental patients with allergies to natural rubber latex. Gen Dent 2002; 50: 526–36
10. Bernstein DI. Management of natural rubber latex allergy. J Allergy Clin Immunol 2002; 110 (suppl 2): S111–S116
11. Nieto A, et al. Efficacy of latex avoidance for primary prevention of latex sensitization in children with spina bifida. J Pediatr 2002; 140: 370–2
12. Hourihane JO’B, et al. Impact of repeated surgical procedures on the incidence and prevalence of latex allergy: a prospective study of 1263 children. J Pediatr 2002; 140: 479–82
13. Cullinan P, et al.. British Society of Allergy and Clinical Immunology. Latex allergy: a position paper of the British Society of Allergy and Clinical Immunology. Clin Exp Allergy 2003; 33: 1484–99
14. LaMontagne AD, et al. Primary prevention of latex related sensitisation and occupational asthma: a systematic review. Occup Environ Med 2006; 63: 359–64
15. Nettis E, et al. Double-blind, placebo-controlled study of sublingual immunotherapy in patients with latex-induced urticaria: a 12-month study. Br J Dermatol 2007; 156: 674–81.
Published May 08, 2019.