💊 Chemical information
CI Acid Red 94; Colour Index No. 45440; Rosa de bengala sódico; Rose Bengal; Sodium Rose Bengal. The disodium salt of 4,5,6,7-tetrachloro-2′,4′,5′,7′-tetraiodofluorescein .
Chemical formula: C20H2Cl4I4Na2O5 = 1017.6.
CAS — 11121-48-5 (rose bengal); 632-69-9 (rose bengal disodium).
ATC — S01JA02.
ATC Vet — QS01J A02.
NOTE. The name Rose Bengale has been applied to the substance described in this monograph as well as to dichlorotetraiodofluorescein (CI Acid Red 93; Ext. D & C Reds Nos. 5 and 6; Colour Index No. 45435), a compound used as its disodium or dipotassium salt as a colouring agent. ROS is a code approved by the BP 2008 for use on single unit doses of eye drops containing rose bengal sodium where the individual container may be too small to bear all the appropriate labelling information.
Rose bengal sodium stains devitalised conjunctival and corneal epithelial cells as well as mucus and is used as an aid in the diagnosis of dry eye. It is used to detect or assess ocular damage resulting from Sjögren’s syndrome or from ill-fitting contact lenses, and for keratitis, squamous cell carcinomas, and detection of foreign bodies. Rose bengal sodium is applied as 1% eye drops or as sterile papers impregnated with the dye. Instillation of this dye may be painful, especially in dry eyes. Rose bengal sodium can stain exposed skin, clothing, and soft contact lenses. Rose bengal sodium should not be used before taking swabs as it possesses some antiviral activity. Rose bengal sodium is taken up by the liver and excreted in the bile; the iodine-131-labelled compound has been used as a diagnostic aid in the determination of hepato-biliary function.
Canad.: Ak-Rose; USA: Rosets.
Published May 08, 2019.