Rilonacept

(USAN, rINN)
Synonyms: IL-1 Trap; Interleukin-1 Receptor; Interleukin-1 Trap; Rilonaceptum.
Cyrillic synonym: Рильонацепт.

💊 Chemical information

CAS — 501081-76-1.

💊 Profile

Rilonacept is an interleukin-1 blocker used in the treatment of cryopyrin-associated periodic syndromes (CAPS) including familial cold auto-inflammatory syndrome (FCAS) and MuckelWells syndrome (MWS), which are rare inherited auto-inflammatory disorders. Rilonacept is a soluble decoy interleukin-1 receptor that binds interleukin-1beta and blocks its actions at cell surfaces. Rilonacept is given by subcutaneous injection. The solution, when prepared according to the manufacturer’s directions, contains 160 mg per 2 mL and this is the maximum amount that should be given as a single injection or at a single site; if a larger dose is required (as at loading) two separate injections should be given on the same day at two different sites. The loading dose is 320 mg (as two separate injections). A single injection of 160 mg is then given once weekly. The loading dose for children aged 12 to 17 years is 4.4 mg/kg up to a maximum of 320 mg (given as one or two injections depending on the dose). A single injection of 2.2 mg/kg up to a maximum of 160 mg is then given once weekly.

💊 Preparations

Proprietary Preparations

USA: Arcalyst.
Published May 08, 2019.