Relaxin

(BAN, USAN, rINN)

Chemical information

Relaxina.
CAS — 9002-69-1.

Profile

Relaxin is a polypeptide hormone that has been extracted from the corpus luteum of the ovaries of pregnant sows, although a human recombinant form is also now available. It is reported to be related structurally to insulin and has a molecular weight of about 6000. Relaxin is secreted by the human corpus luteum during pregnancy and is thought to interact with other reproductive hormones. It acts on connective tissue, including collagen, and causes relaxation of the pubic symphysis and softening of the uterine cervix. In many animal species relaxin appears to play a major part in cervical ripening before parturition; significant species difference is shown. It has been studied for cervical ripening in humans. Recombinant human relaxin has also been investigated in infertility, cardiovascular disorders, and scleroderma.
1. Seibold JR, et al. Safety and pharmacokinetics of recombinant human relaxin in systemic sclerosis. J Rheumatol 1998; 25: 302–7
2. Seibold JR, et al. Recombinant human relaxin in the treatment of scleroderma: a randomized, double-blind, placebo-controlled trial. Ann Intern Med 2000; 132: 871–9
3. Kelly AJ, et al. Relaxin for cervical ripening and induction of labour. Available in The Cochrane Database of Systematic Reviews; Issu
2. John Wiley; Chichester; 2001 (accessed 28/04/06).
Published May 08, 2019.