Polytef

(USAN)
Synonyms: Politef (pINN); Politefo; Politefum; PTFE. Poly(tetrafluoroethylene).
Cyrillic synonym: Политеф.

Chemical information

Chemical formula: (C2F4) n .
CAS — 9002-84-0.

Profile

Polytef has numerous industrial applications. As ‘Teflon’ it is used on ‘non-stick’ cooking utensils. A paste of polytef has been used for a variety of purposes including the treatment of aphonia, for replacement grafts in vascular surgery, and in the correction of some forms of urinary incontinence. The main concern with these procedures is migration of polytef particles. It has also been applied to the skin as a barrier paste with perfluoroalkylpolyether to reduce exposure to chemical warfare agents.

Adverse effects.

Brain injury in a child was possibly associated with migration of polytef particles from a periureteral injection performed 1 year earlier.1 Three cases of polytef adenopathy and one case of giant granuloma have been reported2 in children who had previously undergone subureteral polytef injection for the treatment of vesicoureteral reflux.
1. Borgatti R, et al. Brain injury in a healthy child one year after periureteral injection of Teflon. Pediatrics 1996; 98: 290–1
2. Aragona F, et al. Polytetrafluoroethylene giant granuloma and adenopathy: long-term complications following subureteral polytetrafluoroethylene injection for the treatment of vesicoureteral reflux in children. J Urol (Baltimore) 1997; 158: 1539–42.

Uses.

References.
1. Polley JW, et al. The use of Teflon in orbital floor reconstruction following blunt facial trauma: a 20-year experience. Plast Reconstr Surg 1987; 79: 39–43
2. Puri P. Endoscopic correction of primary vesicoureteric reflux by subureteric injection of polytetrafluoroethylene. Lancet 1990; 335: 1320–2
3. Maskell R, et al. Correction of vesicoureteric reflux by endoscopic injection. Lancet 1991; 338: 1460–1
4. Anonymous. Use of Teflon preparations for urinary incontinence and vesicoureteral reflux. JAMA 1993; 269: 2975–80
5. Duckett JRA. The use of periurethral injectables in the treatment of genuine stress incontinence. Br J Obstet Gynaecol 1998; 105: 390–6
6. Su TH, et al. Injection therapy for stress incontinence in women. Int Urogynecol J 1999; 10: 200–6.
xx xx
7. Chaffange P, et al. Traitement endoscopique du réflux vésicorénal chez l’enfant: résultats à court et à long terme des injections de polytétrafluoroéthylene (Téflon). Prog Urol 2001; 11: 546–51
8. Meschia M, et al. Injection therapy for the treatment of stress urinary incontinence in women. Gynecol Obstet Invest 2002; 54: 67–72
9. Huber TS, et al. Patency of autogenous and polytetrafluoroethylene upper extremity arteriovenous hemodialysis accesses: a systematic review. J Vasc Surg 2003; 38: 1005–11
10. Klinkert P, et al. Saphenous vein versus PTFE for above-knee femoropopliteal bypass: a review of the literature. Eur J Vasc Endovasc Surg 2004; 27: 357–62.
Published May 08, 2019.