Poly I.poly C

Poly I.poly C Chemical formula
Synonyms: Poli (I). poli (C); Polyinosinic-polycytidylic Acid.
Cyrillic synonym: Поли(И).поли(Ц).

Chemical information

Chemical formula: (C10H13N4O8P)x.(C9H14N3O8P)x. CAS — 24939-03-5.
ATC — L03AX07.
ATC Vet — QL03AX07.


Poly I.poly C is a synthetic double-stranded polyribonucleotide complex of equimolar concentrations of polyinosinic and polycytidylic acids, described as a mismatched double-strand RNA. Poly I.poly C and the complex of poly I.poly C stabilised with polyL-lysine in carmellose [poly(ICLC)] have been found to induce the production of interferon and have been investigated in the treatment of malignant neoplasms and viral infections. In the form of poly I.poly C12U it has been investigated for the treatment of AIDS, SARS, avian influenza, chronic fatigue syndrome, renal cell carcinoma, and invasive metastatic melanoma; poly(ICLC) has been investigated for the treatment of primary brain tumours.
Published May 08, 2019.