Poliglusam Hydrochloride

(rINNM)
Synonyms: Chitosan Hydrochloride; Chitosane, chlorhydrate de; Chitosanhydrochlorid; Chitosani hydrochloridum; Chitozano hidrochloridas; Hidrocloruro de poliglusam; Kitosaanihydrokloridi; Kitosanhydroklorid; Kitozán-hidroklorid; Poliglusam, Chlorhydrate de; Poliglusami Hydrochloridum.
Cyrillic synonym: Полиглузама Гидрохлорид.

💊 Chemical information

Pharmacopoeias.

In Eur..

Ph. Eur. 6.2

(Chitosan Hydrochloride). The chloride salt of an unbranched binary heteropolysaccharide consisting of the two units N-acetylD-glucosamine and D-glucosamine, obtained by partial deacetylation of chitin, normally leading to a degree of deacetylation of 70.0 to 95.0%. Chitin is extracted from the shells of shrimp and crab. A white or almost white fine powder. Sparingly soluble in water; practically insoluble in alcohol. A 1% solution in water has a pH of 4.0 to 6.0. Store in airtight containers at a temperature of 2° to 8°. Protect from light.

💊 Profile

Poliglusam is a polysaccharide composed of polymers of glucosamine and N-acetylglucosamine produced by partial deacetylation of chitin. It is manufactured commercially by chemical treatment of crustacean shells. Poliglusam is under investigation as a pharmaceutical excipient for formulations including oral dosage forms and gene carrier systems. It has been used as a dietary supplement in preparations for obesity and hypercholesterolaemia.
1. Ylitalo R, et al. Cholesterol-lowering properties and safety of chitosan. Arzneimittelforschung 2002; 52: 1–7
2. Jull AB, et al. Chitosan for overweight or obesity. Available in The Cochrane Database of Systematic Reviews; Issu
3. Chichester: John Wiley; 2008 (accessed 07/08/08).

💊 Preparations

Proprietary Preparations

Arg.: Chito-Lafarmen; Braz.: Lipenan†; Magrix; UK: Bio Slim Silueta; Formoline L112. Multi-ingredient: Arg.: Exo’Fat†; Redualgas; Braz.: Control; Indon.: Betaslim; Combes; Kitoles; Vitaslim; Malaysia: Chitosan C†; Port.: Lipoabsorver†; Lipoforte†; Redusan Plus†; Singapore: Chitosano; Colenon.
Published May 08, 2019.