Pirfenidone

(USAN, rINN)
Pirfenidone Chemical formula
Synonyms: AMR-69; Pirfenidona; Pirfénidone; Pirfenidonum. 5-Methyl-1phenyl-2(1H)-pyridone.
Cyrillic synonym: Пирфенидон.

Chemical information

Chemical formula: C12H11NO = 185.2.
CAS — 53179-13-8.

Profile

Pirfenidone is an antifibrotic drug under investigation in disorders such as idiopathic pulmonary fibrosis, multiple sclerosis, and familial adenomatous polyposis.
1. Nicod LP. Pirfenidone in idiopathic pulmonary fibrosis. Lancet 1999; 354: 268–9
2. Walker JE, Margolin SB. Pirfenidone for chronic progressive multiple sclerosis. Multiple Sclerosis 2001; 7: 305–12
3. Nagai S, et al. Open-label compassionate use one year-treatment with pirfenidone to patients with chronic pulmonary fibrosis. Intern Med 2002; 41: 1118–23
4. Bowen JD, et al. Open-label study of pirfenidone in patients with progressive forms of multiple sclerosis. Multiple Sclerosis 2003; 9: 280–3
5. Lindor NM, et al. Desmoid tumors in familial adenomatous polyposis: a pilot project evaluating efficacy of treatment with pirfenidone. Am J Gastroenterol 2003;98: 1868–74
6. Azuma A, et al. Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2005; 171: 1040–7
7. Walker JE, et al. A double-blind, randomized, controlled study of oral pirfenidone for treatment of secondary progressive multiple sclerosis. Multiple Sclerosis 2005; 11: 149–58
8. Babovic-Vuksanovic D, et al. Phase II trial of pirfenidone in adults with neurofibromatosis typ
1. Neurology 2006; 67: 1860–2
9. Shi S, et al. Single- and multiple-dose pharmacokinetics of pirfenidone, an antifibrotic agent, in healthy Chinese volunteers. J Clin Pharmacol 2007; 47: 1268–76.
Published May 08, 2019.