Synonyms: OK-432.
Cyrillic synonym: Пицибанил.

💊 Chemical information

CAS — 39325-01-4.

💊 Profile

Picibanil is a lyophilised preparation of a low-virulence strain of Streptococcus pyogenes inactivated by heating with benzylpenicillin; it is reported to act as an immunomodulator. It has been given by injection in the treatment of malignant neoplasms.
1. Luzzatto C, et al. Sclerosing treatment of lymphangiomas with OK-432. Arch Dis Child 2000; 82: 316–18
2. Sakamoto J, et al. Meta-analysis of adjuvant immunochemotherapy using OK-432 in patients with resected non-small-cell lung cancer. J Immunother 2001; 24: 250–6
3. Laranne J, et al. OK-432 (Picibanil) therapy for lymphangiomas in children. Eur Arch Otorhinolaryngol 2002; 259: 274–8
4. Sakamoto J, et al. Efficacy of adjuvant immunochemotherapy with OK-432 for patients with curatively resected gastric cancer: a meta-analysis of centrally randomized controlled clinical trials. J Immunother 2002; 25: 405–12
5. Giguere CM, et al. Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: a prospective multi-institutional trial. Arch Otolaryngol Head Neck Surg 2002; 128: 1137–44
6. Watanabe M, et al. Randomized controlled trial of the efficacy of adjuvant immunochemotherapy and adjuvant chemotherapy for colorectal cancer, using different combinations of the intracutaneous streptococcal preparation OK-432 and the oral pyrimidines 1-hexylcarbamoyl-5-fluorouracil and uracil/tegafur. Int J Clin Oncol 2004; 9: 98–106
7. Sato Y, et al. A randomized controlled study of immunochemotherapy with OK-432 after curative surgery for gastric cancer. J Immunother 2004; 394–7
8. Taniguchi T, et al. Clinical results of OK-432 injection therapy for ganglions. J Dermatol 2005; 32: 262–5
9. Kasahara K, et al. Randomized phase II trial of OK-432 in patients with malignant pleural effusion due to non-small cell lung cancer. Anticancer Res 2006; 26: 1495–9
10. Knipping S, et al. Sclerotherapy of cervical cysts with Picibanil (OK-432). Eur Arch Otorhinolaryngol 2007; 264: 423–7
11. Nygaard U, et al. New treatment of early fetal chylothorax. Obstet Gynecol 2007; 109: 1088–92.

💊 Preparations

Proprietary Preparations

Jpn: Picibanil.
Published May 08, 2019.