Phosgene

(BAN)
Phosgene Chemical formula

💊 Chemical information

Carbonic Dichloride; Carbonyl Chloride; Chloroformyl Chloride; Fosgen; Fosgeno.
Chemical formula: COCl2 = 98.92.
CAS — 75-44-5.

💊 Adverse Effects

Poisoning may occur from industrial use or from the generation of phosgene from chlorinated compounds such as dichloromethane, chloroform, or carbon tetrachloride in the presence of heat. Symptoms of poisoning, which may be delayed for up to 24 (rarely 72) hours, include burning of the eyes and throat, cough, dyspnoea, cyanosis, and pulmonary congestion and oedema. Death may result from anoxia. Exposure to 50 ppm may be rapidly fatal. Massive exposure may cause intravascular haemolysis, thrombus formation, and immediate death. Exertional dyspnoea may persist for months after exposure to high concentrations.

💊 Treatment of Adverse Effects

After inhalation of phosgene or absorption from the skin, treatment consists of complete rest and inhalation of oxygen. The mouth, eyes, nose, and skin should be irrigated with copious amounts of water. Oral or parenteral corticosteroids have been used for bronchospasm but the role of inhaled corticosteroids is considered to be controversial. Antibacterials may reduce respiratory infections. Further treatment is symptomatic.

💊 Uses and Administration

Phosgene is used in the chemical industry. It has been used as a war gas.
1. Borak J, Diller WF. Phosgene exposure: mechanisms of injury and treatment strategies. J Occup Environ Med 2001; 43: 110–9.
Published May 08, 2019.