Phencyclidine Hydrochloride

(BANM, USAN, rINNM)
Phencyclidine Hydrochloride Chemical formula
Synonyms: CI-395; CN-25253-2; GP-121; Hidrocloruro de fenciclidina; NSC-40902; PCP; Phencyclidine, Chlorhydrate de; Phencyclidini Hydrochloridum. 1-(1-Phenylcyclohexyl)piperidine hydrochloride.
Cyrillic synonym: Фенциклидина Гидрохлорид.

💊 Chemical information

Chemical formula: C17H25N,HCl = 279.8.
CAS — 77-10-1 (phencyclidine); 956-90-1 (phencyclidine hydrochloride).
NOTE. The name PCP has also been used as a synonym for pentachlorophenol. The following terms have been used as ‘street names’ or slang names for various forms of phencyclidine: Ace; AD; Aliamba; Amoeba; Amoebae; Amp; Angel; Angel dust; Angel hair; Angel mist; Angel poke; Animal trank; Animal tranq; Animal tranquilizer; Aurora borealis; Bad pizza; Belladonna; Black dust; Black whack; Blotter acid; Blud madman; Blue madman; Boat; Bohd; Bush; Busy bee; Butt naked; Buzy bee; Cadillac; Cannabinol; Christal; Cigarrode cristal; CJ; Cliffhanger; Cliqum; Columbo; Cozmo’s; Crazy coke; Crazy Eddie; Cristal; Crystal; Crystal joint; Crystal T; Crystal TAC; Cycline; Cyclona; Cyclone; Cyclones; Cystal T; D; Detroit pink; Devil’s dust; Dipper; Dips; Dirge; Disembalming Fluid; DMT; Do it Jack; DOA; Drink; Drinks; Dummy dust; Dust; Dust joint; Dust of angels; Dusted parsley; Elephant; Elephant trank; Elephant tranquilizer; Embalming fluid; Energizer; Engelenspul; Erth; Fake STP; Fake THC; Fake X; Flakes; Formaldehyde; Fresh; Fry; Fuel; Good; Goon; Goon crystal; Goon dust; Gorilla biscuits; Gorilla pills; Gorilla tab; Green; Green double domes; Green leaves; Green tea; Green tear; Half track; Happy sticks; HCP; Heaven & Hell; Heaven and Hell; Herms; High; Hinkley; Hog; Horse tracks; Horse tranquilizer; Ice; Ill; Illies; Illy momo; Jet fuel; Juice; K; Kaps; K-blast; Killer; Killer joints; Killer weed; KJ; Koller joints; Kools; Kools sherms; Krystal; Krystal joint; Krystal joints; KW; LBJ; Leak; Leakie; Leaky; Leaky bolla; Leaky leak; Lemon 714; Lenos; Lethal weapon; Little ones; Live ones; Log; Love boat; Loveboat; Lovely; Mad dog; Mad man; Madman; Magic; Magic dust; Mean green; Mesk; Mint leaf; Mint weed; Missile; Mist; Monkey dust; Monkey gland; Monkey tranquilizer; More; New acid; New magic; Niebla; Oil; OPP; O.P.P.; Orange crystal; Ozone; P; Parsley; Paz; PCP; PCPA; Peace; PeaCe Pill; Peace pill; Peace pills; Peace weed; Peep; Peter Pan; Pig killer; Pit; Pits; Po-de-anjo; Polvo; Polvo de angel; Polvo de estralos; Polvo de estrellas; Puffy; Purple rain; Red devil; Red devils; Rocket fuel; Rocketfuel; Rupture; Scaffle; Scuffle; Serenity Tranquility Peace; Sernyl; Sernylan; Shabu; Sheets; Sherm; Sherm sticks; Sherman Hemsley; Shermans; Sherms; Skuffle; Smoking; Snorts; Soma; Space rock; Speed boat; Spores; Star dust; Stardust; Stick; STP; Sugar; Super; Super grass; Super joint; Super kools; Super weed; Supergrass; Surfer; Synthetic cocaine; Synthetic THT; T; TAC; Tac et tic; Taking a cruise; T-buzz; Tea; THC; Tic; Tic tac; Tick; Tic-tac; TicTac; Tish; Titch; Trank; Tranq; Tranquilizer (cat, horse, elephant); TT 1; TT 2; TT 3; Venom; Vredestro; Wack; Water; Wave; Weed; Wet; Wet daddies; Wetdaddy; Whack; White horizon; White powder; Wobble weed; Wolf; Woolies; Wooly blunts; Worm; Yellow fever; Zombie; Zombie weed; Zoom; Zoot.

💊 Adverse Effects, Treatment, and Precautions

Phencyclidine can induce a psychosis clinically indistinguishable from schizophrenia. Adverse effects reported include bizarre and violent behaviour, hallucinations, euphoria, agitation, catatonic rigidity, disorientation, incoordination, nystagmus, hypersalivation, vomiting, convulsions, numbness, hypertension, tachycardia, rhabdomyolysis leading to renal failure, acidosis, and, occasionally, malignant hyperthermia. Severe intoxication may result in respiratory depression, coma, and death. In cases of phencyclidine overdose, activated charcoal should preferably be given within 1 hour of ingestion; multiple doses may be of benefit since phencyclidine is actively secreted into the gastrointestinal tract. Treatment of the adverse effects of phencyclidine is symptomatic; if agitated the patient should be kept quiet in a darkened room, and diazepam given if necessary. Butyrophenone antipsychotics such as haloperidol have been used for severe behavioural problems and psychoses, although they are associated with adverse effects and some suggest that they should generally be avoided. Phenothiazines may lower the seizure threshold and should also be avoided. Hyperthermia should be treated. Renal excretion should be promoted by hydration and use of diuretics if necessary. Acidification of the urine is no longer recommended since acidosis may be exacerbated and renal failure precipitated.

Breast feeding.

The American Academy of Pediatrics1 has stated that, when used as a drug of abuse by a breast-feeding mother, phencyclidine has caused hallucinogenic effects in the infant.
1. American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001; 108: 776–89. Correction. ibid.; 1029. Also available at: http://aappolicy.aappublications.org/cgi/content/full/ pediatrics%3b108/3/776 (accessed 02/07/04)

💊 Uses and Administration

Phencyclidine is related chemically to ketamine and is a potent analgesic and anaesthetic. It was formerly given intravenously to produce an amnesic trance-like state, with analgesia, but severe adverse effects, especially postoperative psychoses, precluded its use. It was formerly used in veterinary medicine as an immobilising agent. Phencyclidine is widely abused in some countries for its hallucinogenic effects and has been taken orally, sniffed, injected, or smoked. Numerous analogues of phencyclidine have been similarly abused and include:
PHP (rolicyclidine; 1-(1-phenylcyclohexyl)pyrrolidine)
PCC (1-piperidinocyclohexanecarbonitrile)
PCE (N-ethyl-1-phenylcyclohexylamine)
TCP (1-[1-(2-thienyl)cyclohexyl]piperidine)
Published May 08, 2019.