Perflubron

(USAN, rINN)
Perflubron Chemical formula
Synonyms: Perflubrón; Perflubronum; Perfluorooctylbromide; PFOB. 1-Bromoheptadecafluorooctane.
Cyrillic synonym: Перфлуброн.

💊 Chemical information

Chemical formula: C8BrF17 = 499.0.
CAS — 423-55-2.
ATC — V08CX01.
ATC Vet — QV08C X01.

Pharmacopoeias.

In US.

USP 31

(Perflubron). A clear, colourless, practically odourless liquid. Store in airtight containers. Protect from light.

💊 Profile

Perfluorocarbons can absorb, transport, and release oxygen and carbon dioxide. Perflubron is a perfluorocarbon tried as an alternative to red blood cell preparations to improve gaseous transport, in particular oxygen supply, to the tissues. It may also be instilled directly to the lungs for use in partial liquid ventilation as an adjunct to mechanical ventilation in patients with respiratory failure. Perflubron is being studied for use as an intravenous contrast medium in computed tomography and ultrasound. It has also been given orally to enhance delineation of the bowel during magnetic resonance imaging. Other perfluorocarbons have also been used. A mixture of perfluamine (perfluorotripropylamine) and perflunafene has been used to prevent myocardial ischaemia during percutaneous transluminal coronary angioplasty. Perfluorocarbons such as perflunafene and perfluorooctane have been used in eye surgery.

Blood substitutes.

References to the use of perflubron and other perfluorocarbons as oxygen carriers.
1. Garrelts JC. Fluosol: an oxygen-delivery fluid for use in percutaneous transluminal coronary angioplasty. DICP Ann Pharmacother 1990; 24: 1105–12
2. Ravis WR, et al. Perfluorochemical erythrocyte substitutes: disposition and effects on drug distribution and elimination. Drug Metab Rev 1991; 23: 375–411
3. Urbaniak SJ. Artificial blood. BMJ 1991; 303: 1348–50
4. Jones JA. Red blood cell substitutes: current status. Br J Anaesth 1995; 74: 697–703
5. Remy B, et al. Red blood cell substitutes: fluorocarbon emulsions and haemoglobin solutions. Br Med Bull 1999; 55: 277–98
6. Lowe KC. Perfluorinated blood substitutes and artificial oxygen carriers. Blood Rev 1999; 13: 171–84
7. Prowse CV. Alternatives to standard blood transfusion: availability and promise. Transfus Med 1999; 9: 287–99
8. Matsumoto S, Kuroda Y. Perfluorocarbon for organ preservation before transplantation. Transplantation 2002; 74: 1804–9
9. Jahr JS, et al. Blood substitutes and oxygen therapeutics: an overview and current status. Am J Ther 2002; 9: 437–43
10. Kim HW, Greenburg AG. Artificial oxygen carriers as red blood cell substitutes: a selected review and current status. Artif Organs 2004; 28: 813–28
11. Spahn DR, Kocian R. Artificial O2 carriers: status in 2005. Curr Pharm Des 2005; 11: 4099–4114
12. Riess JG. Perfluorocarbon-based oxygen delivery. Artif Cells Blood Substit Immobil Biotechnol 2006; 34: 567–80.

Respiratory distress syndrome.

References to the use of perfluorocarbons, including perflubron, for partial liquid ventilation in neonatal respiratory distress syndrome and acute respiratory distress syndrome.
1. Hirschl RB, et al. Liquid ventilation in adults, children, and fullterm neonates. Lancet 1995; 346: 1201–2
2. Leach CL, et al. Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome. N Engl J Med 1996; 335: 761–7
3. Hirschl RB, et al. Initial experience with partial liquid ventilation in adult patients with acute respiratory distress syndrome. JAMA 1996; 275: 383–9
4. Wolfson MR, Shaffer TH. Liquid assisted ventilation update. Eur J Pediatr 1999; 158: S27–S31
5. Davies M. Liquid ventilation. J Paediatr Child Health 1999; 35: 434–7
6. Weis CM, Fox WW. Current status of liquid ventilation. Curr Opin Pediatr 1999; 11: 126–32
7. Kacmarek RM. Liquid ventilation. Respir Care Clin N Am 2002; 8: 187–209
8. Davies MW, Fraser JF. Partial liquid ventilation for preventing death and morbidity in adults with acute lung injury and acute respiratory distress syndrome. Available in The Cochrane Database of Systematic Reviews; Issu
4. Chichester: John Wiley; 2004 (accessed 28/04/05).

💊 Preparations

Proprietary Preparations

USA: Imagent GI; LiquiVent.
Published May 08, 2019.