Pepsin

(BAN, USAN, rINN)

💊 Chemical information

Pepsiini; Pepsiinijauhe; Pepsin práškový; Pepsin, pulver; Pepsina; Pepsine; Pepsini Pulvis; Pepsino milteliai; Pepsinum; Pepszin-por.
CAS — 9001-75-6.
ATC — A09AA03.
ATC Vet — QA09AA03.

Pharmacopoeias.

In Chin., Eur., and Viet. In Jpn as Saccharated Pepsin.

Ph. Eur. 6.2

(Pepsin Powder; Pepsin BP 2008). It is prepared from the gastric mucosa of pigs, cattle, or sheep. It contains gastric proteinases active in acid medium (pH 1 to 5). It has an activity of not less than 0.5 Ph. Eur. units/mg, calculated with reference to the dried substance. A hygroscopic, white or slightly yellow, crystalline or amorphous powder. Soluble in water; practically insoluble in alcohol. A solution in water may be slightly opalescent with a weak acidic reaction. Store at 2° to 8° in airtight containers. Protect from light.

💊 Uses and Administration

Pepsin contains proteolytic enzymes secreted by the stomach, which control the degradation of proteins into proteoses and peptones. It hydrolyses polypeptides including those with bonds adjacent to aromatic or dicarboxylic L-amino-acid residues. Pepsin has been given with dilute hydrochloric acid, or with substances such as glutamic acid hydrochloride, or betaine hydrochloride, as an adjunct in the treatment of gastric hypochlorhydria, or to treat deficiencies of digestive enzyme secretion. It has also been given for its supposed benefit as an ingredient of mixtures for dyspepsia and other gastrointestinal disorders.

💊 Preparations

Proprietary Preparations

Canad.: Fermentol; Ger.: Hettral N†; Pol.: Mixtura Pepsini. Multi-ingredient: Arg.: Docechol; Gastridin-E; Opoenterol†; Tridigestivo Soubeiran; Austral.: Betaine Digestive Aid; Bioglan Digestive Zyme; Digestaid; Enzyme; Prozyme†; Austria: Helo-acid; Helopanzym; Oroacid; Belg.: Digestomen; Braz.: Digeplus; Essen; Filogaster†; Hepatoregius†; Pantopept†; Peptopancreasi; Primeral; Chile: Flapex E; Ger.: Citropepsin†; Pepzitrat; Hung.: Betacid; India: Aristozyme; Digeplex; Digeplex-T; Dipep; Lupizyme; Nutrozyme; Papytazyme; Indon.: Librozym; Librozym Plus; Israel: Babyzim; Betazim; Ital.: Digestopan†; Essen Enzimatico†; Eudigestio†; Gastro-Pepsin; Pepto-Pancreasi†; Mex.: Ochozim; Zimotris; Philipp.: Spasmo-Canulase; Pol.: Citropepsin; Port.: Espasmo Canulase; Modulanzime; S.Afr.: Sentinel Ulcer Mixture; Spasmo-Canulase; Spain: Digestomen Complex; Euzymina Lisina I; Euzymina Lisina II; Troforex Pepsico; Switz.: Pepsi-Chlor†; Spasmo-Canulase; Stomacine; Thai.: Papytazyme†; Pepsitase; UK: Enzyme Plus; USA: Digepepsin.
Published May 08, 2019.