Pentagastrin

(BAN, USAN, rINN)
Pentagastrin Chemical formula
Synonyms: AY-6608; ICI-50123; Pentagastriini; Pentagastrina; Pentagastrine; Pentagastrinum. tertButyloxycarbonyl-[ 13 ]gastrin-(13-17)pentapeptide amide; Boc2 .
Cyrillic synonym: Пентагастрин.

💊 Chemical information

Chemical formula: C37H49N7O9S = 767.9.
CAS — 5534-95-2.
ATC — V04CG04.
ATC Vet — QV04CG04.

Pharmacopoeias.

In Br. and Chin.

BP 2008

(Pentagastrin). A white or almost white powder. Practically insoluble in water; slightly soluble in alcohol; soluble in dimethylformamide and in 5M ammonia. Protect from light.

💊 Adverse Effects

Pentagastrin may cause gastrointestinal effects including nausea and abdominal cramps. Cardiovascular effects including flushing of the skin, tachycardia, and hypotension have occasionally been reported. There may be headache, drowsiness, dizziness, and altered sensations in the extremities. Hypersensitivity reactions are rare.

💊 Precautions

Pentagastrin should be given with care to patients with acute peptic ulceration or with active pancreatic, hepatic, or biliary-tract disease.

💊 Uses and Administration

Pentagastrin is a synthetic pentapeptide that is not active when given by mouth but when given parenterally has effects similar to those of natural gastrin. Since it stimulates the secretion of gastric acid, pepsin, and intrinsic factor, it is used as a diagnostic agent to test the secretory action of the stomach. It has been used to diagnose disorders associated with increased or decreased gastric acid secretion and in the evaluation of gastric acid secretion following vagotomy or gastric resection. The usual dose is 6 micrograms/kg by subcutaneous or intramuscular injection. By intravenous infusion the dose is 600 nanograms/kg per hour, in sodium chloride 0.9%. Pentagastrin stimulates the secretion of pancreatic enzymes and thus has been used as a test for pancreatic function. It has also been tried in the diagnosis of medullary carcinoma of the thyroid.

💊 Preparations

BP 2008: Pentagastrin Injection.

Proprietary Preparations

Fr.: Peptavlon.
Published May 08, 2019.