💊 Chemical information

Benzylpenicilloyl-polylysine; Peniciloil polilisina; PO-PLL; PPL.
CAS — 53608-77-8.


Penicilloyl-polylysine is a polypeptide compound formed by the interaction of a penicillanic acid and polylysine of an average degree of polymerisation of 20 lysine residues per molecule.


US includes a concentrated form.

USP 31

(Benzylpenicilloyl Polylysine Concentrate). It has a molar concentration of benzylpenicilloyl moiety of not less than 0.0125 M and not more than 0.020 M. It contains one or more suitable buffers. It is not intended for direct administration. pH of the concentrate is between 6.5 and 8.5. Store in airtight containers.

💊 Adverse Effects and Precautions

Severe hypersensitivity reactions have occasionally been reported after use of penicilloyl-polylysine; a scratch test is recommended before intradermal use.

💊 Uses and Administration

Penicilloyl-polylysine is used to detect penicillin hypersensitivity. It is generally indicated only for adults with a history of penicillin hypersensitivity. After a preliminary scratch test it may then be given by intradermal injection. The development, usually within 5 to 15 minutes, of a wheal, erythema, and pruritus is generally judged a positive reaction. The incidence of penicillin hypersensitivity is stated to be less than 5% in patients showing a negative reaction. Penicilloyl-polylysine does not detect those liable to suffer late reactions or reactions due to minor antigen determinants; these reactions require other tests. False-positive reactions to penicilloyl-polylysine also occur.

💊 Preparations

USP 31: Benzylpenicilloyl Polylysine Injection.

Proprietary Preparations

USA: Pre-Pen†.
Published May 08, 2019.