💊 Chemical information
CCK-PZ; Pancreocimina; Pankreotsymiini; Pankreozymin.
ATC — V04CK02.
ATC Vet — QV04CK02.
NOTE. The endogenous hormone is known as cholecystokinin (CCK).
The potency of pancreozymin may be expressed as Crick-Harper-Raper units based on the pancreatic secretion in cats or as Ivy dog units based on the increase in gallbladder pressure. One Ivy dog unit is considered to be approximately equivalent to 1 CrickHarper-Raper unit.
Pancreozymin is a polypeptide hormone prepared from the duodenal mucosa of pigs. When given by intravenous injection it causes an increase in the secretion of pancreatic enzymes and stimulates gallbladder contraction. Pancreozymin has been used, usually with secretin, as a test for exocrine pancreatic function and in the diagnosis of biliary-tract disorders; these tests generally involved duodenal intubation of the patient and examination of duodenal aspirate. Pancreozymin has also been used as an adjunct to cholecystography. Vasomotor reactions, abdominal discomfort, and hypersensitivity have been reported.
Biliary-tract disorders.It was concluded that cholecystokinin provocation testing was ineffective in predicting which patients with acalculous biliary pain would receive symptomatic relief from cholecystectomy in a study involving 58 patients.1
1. Smythe A, et al. A requiem for the cholecystokinin provocation test? Gut 1998; 43: 571–4.
Published May 08, 2019.