Ornipressin

(rINN)
Synonyms: Ornipresina; Ornipressine; Ornipressinum. [8-Ornithine]-vasopressin.
Cyrillic synonym: Орнипрессин.

💊 Chemical information

Chemical formula: C45H63N13O12S2 = 1042.2.
CAS — 3397-23-7.
ATC — H01BA05.
ATC Vet — QH01B A05.

💊 Profile

Ornipressin is a synthetic derivative of vasopressin with similar actions. It is reported to be a strong vasoconstrictor with only weak antidiuretic properties and is used to reduce bleeding during surgery. A solution containing up to 5 units in 20 to 60 mL of sodium chloride 0.9% is infiltrated into the area involved. Ornipressin is also used for bleeding oesophageal varices in a dose of 20 units diluted in 100 mL of sodium chloride 0.9% given as a continuous intravenous infusion over 48 hours.
1. Kam PC, Tay TM. The pharmacology of ornipressin (POR-8): a local vasoconstrictor used in surgery. Eur J Anaesthesiol 1998; 15: 133–9
2. De Kock M, et al. Ornipressin (Por 8): an efficient alternative to counteract hypotension during combined general/epidural anesthesia. Anesth Analg 2000; 90: 1301–7.

Adverse effects.

Acute pulmonary oedema occurred in a patient after infiltration of ornipressin (12 units in 40 mL isotonic saline) as a local vasoconstrictor during surgery.1 It was suggested that no more than 100 milliunits/kg should be given in this manner.
1. Borgeat A, et al. Acute pulmonary oedema following administration of ornithine-8-vasopressin. Br J Anaesth 1990; 65: 548–51.

Hepatorenal syndrome.

Ornipressin has been found to be of benefit1-4 in the hepatorenal syndrome, a form of renal insufficiency associated with cirrhosis of the liver, and thought to be due to severe renal vasoconstriction secondary to systemic arterial vasodilatation. However, caution in its use has been urged2because of the risk of ischaemic complications.
1. Lenz K, et al. Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis: effects on renal hemodynamics and atrial natriuretic factor. Gastroenterology 1991; 101: 1060–7
2. Guevara M, et al. Reversibility of hepatorenal syndrome by prolonged administration of ornipressin and plasma volume expansion. Hepatology 1998; 27: 35–41
3. Gülberg V, et al. Long-term therapy and retreatment of hepatorenal syndrome type 1 with ornipressin and dopamine. Hepatology 1999; 30: 870–5
4. Restuccia T, et al. Effects of treatment of hepatorenal syndrome before transplantation on posttransplantation outcome: a casecontrol study. J Hepatol 2004; 40: 140–6.

💊 Preparations

Proprietary Preparations

Austral.: POR 8; Austria: POR 8; NZ: POR 8; S.Afr.: POR 8.
Published May 08, 2019.