Opebacan

(BAN, USAN, rINN)
Synonyms: Opébacan; Opebacán; Opebacanum; rBPI-21. 132L-Alanine-1193-bactericidal/permeability-increasing protein (human).
Cyrillic synonym: Опебакан.

Chemical information

CAS — 206254-79-7.

Profile

Bactericidal permeability increasing protein is produced by human leucocytes and possesses both Gram-negative bactericidal and endotoxin-neutralising properties. It also inhibits angiogenesis. Several derivatives have been developed and are under investigation. Opebacan is a modified recombinant fragment of bactericidal permeability increasing protein that is under investigation for the treatment of Crohn’s disease and meningococcal septicaemia. Other derivatives of bactericidal permeability increasing protein are under investigation for retinopathies and acne. Bactericidal permeability increasing protein also possesses antifungal activity.
1. Giroir BP, et al. Preliminary evaluation of recombinant aminoterminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis. Lancet 1997; 350: 1439–43
2. Levin M, et al. Recombinant bactericidal/permeability-increasing protein (rBPI ) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. Lancet 2000; 356: 961–7
3. Levy O. A neutrophil-derived anti-infective molecule: bactericidal/permeability-increasing protein. Antimicrob Agents Chemother 2000; 44: 2925–31
4. van der Schaft DW, et al. The antiangiogenic properties of bactericidal/permeability-increasing protein (BPI). Ann Med 2002; 34: 19–27.
Published January 06, 2019.