Nutmeg

(USAN, rINN)

💊 Chemical information

Muscade; Myristica; Noz Moscada; Nuez moscada; Nux Moschata.

Description.

Nutmeg consists of the dried kernels of the seeds of Myristica fragrans (Myristicaceae), containing not less than 5% v/w of volatile oil; the powdered drug contains not less than 4% v/w. Mace is the dried arillus of the seed of M. fragrans.

Pharmacopoeias.

In Chin.

💊 Adverse Effects

Nutmeg, taken in large doses, may cause nausea and vomiting, flushing, dry mouth, tachycardia, stimulation of the CNS possibly with epileptiform convulsions, miosis or occasionally mydriasis, euphoria, and hallucinations. Myristicin and elimicin are thought to be the constituents responsible for the psychotic effects of nutmeg, possibly because of metabolism to amfetaminelike compounds.
1. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. BMJ 1970; 1: 754
2. Venables GS, et al. Nutmeg poisoning. BMJ 1976; 1: 96
3. Dietz WH, Stuart MJ. Nutmeg and prostaglandins. N Engl J Med 1976; 294: 503
4. Faguet RA, Rowland KF. "Spice cabinet" intoxication. Am J Psychiatry 1978; 135: 860–1
5. Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992; 10: 429–30
6. Brenner N, et al. Chronic nutmeg psychosis. J R Soc Med 1993; 86: 179–80
7. Quin GI, et al. Nutmeg intoxication. J Accid Emerg Med 1998; 15: 287–8
8. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. J Toxicol Clin Toxicol 2000; 38: 671–8
9. Stein U, et al. Nutmeg (myristicin) poisoning—report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001; 118: 87–90.

💊 Uses and Administration

Nutmeg is the source of nutmeg oil (below). It is aromatic and carminative and is used as a flavour. Nutmeg has been reported to inhibit prostaglandin synthesis.

Homoeopathy.

Nutmeg has been used in homoeopathic medicines under the following names: Myristica fragrans; Nux moschata; Nux. mos.

💊 Preparations

Proprietary Preparations

Multi-ingredient: Austria: Mariazeller; Braz.: Paratonico; Cz.: Dr Theiss Schwedenbitter; Klosterfrau Melisana; Naturland Grosser Swedenbitter†; Original Schwedenbitter; Ger.: Doppelherz Melissengeist†; Melissengeist; Pol.: Melisana Klosterfrau; Rus.: Doppelherz Melissa (Доппельгерц Мелисса); Fitovit (Фитовит); Himcolin (Химколин); Original Grosser Bittner Balsam (Оригинальный Большой Бальзам Биттнера); S.Afr.: Entressdruppels HM; Melissengeist; Rooilavental; Spiritus Contra Tussim Drops; Spain: Agua del Carmen; Switz.: Alcoolat de Melisse†; UK: Melissa Comp..
Published May 08, 2019.