Synonyms: Acide Zymonucléique; Acidum Nucleicum; Nucleico, ácido; Nucleinic Acid.
Cyrillic synonym: Нуклеиновая Кислота.
Nucleic acids, which are present in all cellular organisms and viruses, are composed of high molecular weight polynucleotides. A nucleotide is a phosphate ester of a nucleoside, which is made up of either a purine or pyrimidine nitrogenous base attached to a pentose sugar by an N-glycosidic linkage. Diester phosphate linkages between the sugar moieties produce a polynucleotide strand. Nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Synthetic or recombinant nucleic acids are used in gene therapy. Since the administration of nucleic acid gives rise to a marked temporary leucocytosis (usually preceded by a short period of leucopenia) it was formerly given in the treatment of a variety of bacterial infections in the hope of enhancing the natural defence mechanisms. Its therapeutic value, however, has never been established.
Published May 08, 2019.