Nicergoline Chemical formula
Synonyms: FI-6714; Nicergolin; Nicergolina; Nicergolinas; Nicergolinum; Nisergoliini; Nisergolin. 10 methyl 5-bromonicotinate.
Cyrillic synonym: Ницерголин.

💊 Chemical information

Chemical formula: C24H26BrN3O3 = 484.4.
CAS — 27848-84-6.
ATC — C04 AE02.
ATC Vet — QC0 4AE02.


In Eur. and Jpn.

Ph. Eur. 6.2

(Nicergoline). A fine to granular white or yellowish powder. It exhibits polymorphism. Practically insoluble in water; soluble in alcohol; freely soluble in dichloromethane.

💊 Adverse Effects and Precautions

Adverse effects that may occur after nicergoline include gastrointestinal disturbances and, particularly after parenteral doses, hypotension.

Incidence of adverse effects.

Adverse effects occurred in 25 of 359 patients with cerebrovascular insufficiency treated with nicergoline for 1 month;1 the drug had to be withdrawn in 11. The reactions included 6 cases of hot flushes, 8 of general malaise, 2 of agitation, 3 of hyperacidity, 1 of nausea, 3 of diarrhoea, and 2 of dizziness and somnolence.
1. Dauverchain J. Bedeutung von Nicergolin bei der symptomatischen Behandlung des arteriellen Hochdrucks und der chronischen, zerebro-vaskulären Insuffizienz. Arzneimittelforschung 1979; 29: 1308–10.


Nicergoline is considered to be unsafe in patients with porphyria because it has been shown to be porphyrinogenic in in-vitro systems, although there is conflicting evidence of porphyrinogenicity.

💊 Interactions

For a study indicating that nicergoline enhances the cardiac depressant action of propranolol, see Ergot Derivatives, in Interactions of Beta Blockers.

💊 Uses and Administration

Nicergoline is an ergot derivative. It has been used similarly to codergocrine mesilate to treat symptoms of mental deterioration associated with cerebrovascular insufficiency and has also been used in peripheral vascular disease. Nicergoline has been given in doses of up to 60 mg daily by mouth in divided doses, and by intramuscular injection in doses of 2 to 4 mg twice daily; 4 to 8 mg daily has been given by intravenous infusion. Nicergoline tartrate has been used in parenteral dosage forms.
1. Ronchi F, et al. Symptomatic treatment of benign prostatic obstruction with nicergoline: a placebo controlled clinical study and urodynamic evaluation. Urol Res 1982; 10: 131–4
2. Bousquet J, et al. Double-blind, placebo-controlled study of nicergoline in the treatment of pruritus in patients receiving maintenance hemodialysis. J Allergy Clin Immunol 1989; 83: 825–8
3. Saletu B, et al. Nicergoline in senile dementia of Alzheimer type and multi-infarct dementia: a double-blind, placebo-controlled, clinical and EEG/ERP mapping study. Psychopharmacology (Berl) 1995; 117: 385–95
4. Herrmann WM, et al. A multicenter randomized double-blind study on the efficacy and safety of nicergoline in patients with multi-infarct dementia. Dementia Geriatr Cogn Disord 1997; 8: 9–17
5. Fioravanti M, Flicker L. Nicergoline for dementia and other age associated forms of cognitive impairment. Available in The Cochrane Database of Systematic Reviews; Issu
4. Chichester: John Wiley; 2001 (accessed 28/04/05)
6. Felisati G, et al. Nicergoline in the treatment of dizziness in elderly patients: a review. Arch Gerontol Geriatr Suppl 2004; 163–70.

💊 Preparations

Proprietary Preparations

Arg.: Cergodun; Nicergolent†; Sermion; Austria: Ergotop; Nicergin; Sermion; Braz.: Sermion; Chile: Sermion; Cz.: Ergotop; Nilogrin†; Sermion; Fr.: Sermion; Ger.: Circo-Maren†; Ergobel; Nicergobeta; Nicerium; Sermion†; Gr.: Albotyl†; Sermion; Hong Kong: Cergodun; Qualigoline; Sermion; Hung.: Ergotop; Sermion; Indon.: Serolin; Ital.: Cebran; Nicer†; Sermion; Jpn: Sermion; Mex.: Sermion; Philipp.: Sermion; Pol.: Adavin; Circulat; Nicerin; Nilogrin; Sermion; Port.: Erg XXI†; Sermion; Rus.: Nilogrin (Нилогрин); Sermion (Сермион); Spain: Fisifax†; Sermion; Varson; Switz.: Sermion; Thai.: Sermion; Turk.: Sermion; Venez.: Sermion. Multi-ingredient: Arg.: Angiolit†; Sibelium Plus.
Published May 08, 2019.