Nafamostat Mesilate

Nafamostat Mesilate Chemical formula
Synonyms: FUT-175; Mesilato de nafamostat; Nafamostat, Mésilate de; Nafamostat Mesylate naphthyl p-guanidinobenzoate dimethanesulfonate.
Cyrillic synonym: Нафамостата Мезилат.

Chemical information

Chemical formula: C21H25N5O8S2 = 539.6.
CAS — 81525-10-2 (nafamostat); 82956-11-4 (nafamostat mesilate).


Like aprotinin nafamostat is a proteolytic enzyme inhibitor. The mesilate is used in the treatment of acute pancreatitis and disseminated intravascular coagulation, and as an anticoagulant in haemodialysis. Hyperkalaemia has been reported.
1. Yanamoto H, et al. Therapeutic trial of cerebral vasospasm with the serine protease inhibitor, FUT-175, administered in the acute stage after subarachnoid hemorrhage. Neurosurgery 1992; 30: 358–63
2. Akizawa T, et al. Nafamostat mesilate: a regional anticoagulant for haemodialysis in patients at high risk for bleeding. Nephron 1993; 64: 376–81
3. Miyata T, et al. Effectiveness of nafamostat mesilate on glomerulonephritis in immune-complex diseases. Lancet 1993; 341: 1353
4. Murase M, et al. Nafamostat mesilate reduces blood loss during open heart surgery. Circulation 1993; 88: 432–6
5. Kitagawa H, et al. Hyperkalaemia due to nafamostat mesylate. N Engl J Med 1995; 332: 687
6. Yamazato M, et al. Severe abdominal pain associated with allergic reaction to nafamostat mesilate in a chronic hemodialysis patient. Intern Med 2002; 41: 864–6
7. Kaminishi Y, et al. Effects of nafamostat mesilate and minimaldose aprotinin on blood-foreign surface interactions in cardiopulmonary bypass. Ann Thorac Surg 2004; 77: 644–50
8. Ota T, et al. Cardiopulmonary bypass using nafamostat mesilate for patients with infective endocarditis and recent intracranial hemorrhage. Interact Cardiovasc Thorac Surg 2007; 6: 270–3.
Published May 08, 2019.