Nadide

(BAN, USAN, rINN)
Synonyms: Codehydrogenase I; Coenzyme I; Co-I; Diphosphopyridine Nucleotide; DPN; NAD; Nadida; Nadidum; Nicotinamide Adenine Dinucleotide; NSC-20272. 1-(3-Carbamoylpyridinio)furanoside 5-(adenosine-5′-pyrophosphate).
Cyrillic synonym: Надид.

💊 Chemical information

Chemical formula: C21H27N7O14P2 = 663.4.
CAS — 53-84-9.

💊 Profile

Nadide is a naturally occurring coenzyme claimed to be of value in the treatment of alcohol and opioid addiction. The reduced form of nadide, NADH, has been used in the management of chronic fatigue syndrome.

Parkinsonism.

The reduced form of nadide, NADH ( βNADH; reduced DPN) and its phosphate derivative (NADPH) have been given in the management of Parkinson’s disease in an attempt to enhance endogenous dopamine synthesis by stimulating the enzyme tyrosine hydroxylase. Although some beneficial effects have been reported in several case series, a placebo-controlled study failed to find any evidence of efficacy and the routine use of NADH has not been recommended.1
1. Swerdlow RH. Is NADH effective in the treatment of Parkinson’s disease? Drugs Aging 1998; 13: 263–8.

💊 Preparations

Proprietary Preparations

S.Afr.: DPN; Spain: Nad.
Published May 08, 2019.