Metergoline

(BAN, rINN)
Synonyms: FI-6337; MCE; Metergoliini; Metergolin; Metergolina; Métergoline; Metergolinum; Methergoline. Benzyl (8S,10S)-(1,6-dimethylergolin-8-ylmethyl)carbamate.
Cyrillic synonym: Метэрголин.

💊 Chemical information

Chemical formula: C25H29N3O2 = 403.5.
CAS — 17692-51-2.
ATC — G02CB05.
ATC Vet — QG02CB05.

💊 Profile

Metergoline, an ergot derivative, is a dopamine agonist with actions and uses similar to those of bromocriptine. It is also a serotonin antagonist. Metergoline has been used similarly to bromocriptine in disorders associated with hyperprolactinaemia in usual oral doses of 12 mg daily in divided doses; up to 24 mg daily has been given in hyperprolactinaemic men. It has also been used orally to inhibit lactation, for the treatment of gastrointestinal disorders, and for the prophylaxis of migraine and other vascular headaches.

Hyperprolactinaemia and prolactinomas.

Dopamine agonists have been widely used for the treatment of hyperprolactinaemia secondary to a prolactinoma. Metergoline has been tried in patients intolerant of bromocriptine.1 In this report metergoline lowered plasma-prolactin concentrations, although not to normal, in 3 men and 8 women with hyperprolactinaemia. Galactorrhoea was abolished and/or a regular menstrual cycle established in 5 of the women. Prolactin concentrations and symptoms were unchanged in 3 further women with normoprolactinaemic galactorrhoea.
1. Casson IF, et al. Intolerance of bromocriptine: is metergoline a satisfactory alternative? BMJ 1985; 290: 1783–4.

Migraine.

Although metergoline has been used in some countries for the prophylaxis of migraine it is not usually considered to be the drug of choice or even one of the main alternatives.

💊 Preparations

Proprietary Preparations

Ger.: Liserdol; Hong Kong: Liserdol†; Ital.: Liserdol; Singapore: Liserdol†; Switz.: Liserdol†.
Published May 08, 2019.