Melaleuca Oil

(BAN, rINN)

💊 Chemical information

Australian Tea Tree Oil; Melaleuca, aceite de; Mélaleuca, huile essentielle de; Melaleucae aetheroleum; Melaleucae Etheroleum; Mirteniu eterinis aliejus; Oleum Melaleucae; Silice kajeputu střídavolistého; Tea Tree Oil; Teepuuöljy; Teträdolja.
CAS — 68647-73-4; 8022-72-8.

Pharmacopoeias.

In Eur..

Ph. Eur. 6.2

(Tea Tree Oil). The essential oil obtained by steam distillation from the foliage and terminal branchlets of Melaleuca alternifolia, M. linariifolia, M. dissitiflora, and/or other species of Melaleuca. It contains less than 7.0% aromadendrene, less than 15% cineole, 0.5 to 12.0% p-cymene, 0.5 to 4.0% limonene, 1.0 to 6.0% α-pinene, less than 3.5% sabinene, 5.0 to 13.0% α-terpinene, 10.0 to 28.0% γ-terpinene, minimum of 30% terpinen-4-ol, 1.5 to 8.0% α-terpineol, and 1.5 to 5.0% terpinolene. A clear, mobile, colourless to pale yellow liquid with a characteristic odour. Store in well-filled airtight containers at a temperature not exceeding 25°. Protect from light.

💊 Profile

Melaleuca oil has bactericidal and fungicidal properties and is used topically for various skin disorders. It is also used in aromatherapy.
1. Carson CF, et al. Efficacy and safety of tea tree oil as a topical antimicrobial agent. J Hosp Infect 1998; 40: 175–8
2. Allen P. Tea tree oil: the science behind the antimicrobial hype. Lancet 2001; 358: 1245
3. Satchell AC, et al. Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: a randomized, placebo-controlled, blinded study. Australas J Dermatol 2002; 43: 175–8
4. Hammer KA, et al. In vitro activity of Melaleuca alternifolia (tea tree) oil against dermatophytes and other filamentous fungi. J Antimicrob Chemother 2002; 50: 195–9
5. Satchell AC, et al. Treatment of dandruff with 5% tea tree oil shampoo. J Am Acad Dermatol 2002; 47: 852–5
6. Koh KJ, et al. Tea tree oil reduces histamine-induced skin inflammation. Br J Dermatol 2002; 147: 1212–7
7. Mozelsio NB, et al. Immediate systemic hypersensitivity reaction associated with topical application of Australian tea tree oil. Allergy Asthma Proc 2003; 24: 73–5
8. Perrett CM, et al. Tea tree oil dermatitis associated with linear IgA disease. Clin Exp Dermatol 2003; 28: 167–70
9. Hammer KA, et al. Antifungal effects of Melaleuca alternifolia (tea tree) oil and its components on Candida albicans, Candida glabrata and Saccharomyces cerevisiae. J Antimicrob Chemother 2004; 53: 1081–5
10. Hammer KA, et al. A review of the toxicity of Melaleuca alternifolia (tea tree) oil. Food Chem Toxicol 2006; 44: 616–25
11. Carson CF, et al. Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties. Clin Microbiol Rev 2006; 19: 50–62.

💊 Preparations

Proprietary Preparations

Austral.: Clean Skin Anti Acne; Rapaid Antiseptic†; Rapaid Itch Relief; Chile: Acnoxyl Gel Cuidado Intensivo†; Acnoxyl Gel De Limpieza†; Acnoxyl Stick Corrector†; Sebolic; Fr.: Myleuca; Israel: Burnshield; Malaysia: MOOV; Singapore: Rapaid†; UK: Burnshield Gel; Melavir. Multi-ingredient: Arg.: Aveno; Austral.: Apex Repel Natural; APR Cream†; Clean Skin Face Wash; Curaderm†; Neutralice; Rapaid Rash-Relief; SP Cream†; VR†; Chile: Acnoxyl Abrasivo; Acnoxyl Gel Humectante; Acnoxyl Jabon Liquido; Acnoxyl Jabon†; Acnoxyl Locion Tonica; Acnoxyl Shampoo Cabello Graso†; Fr.: Cicatridine; Dermocica; Mycogel; Phytosquame; Squaphane P; Hong Kong: Mycogel; Ital.: Proctopure; Malaysia: T3 Acne; NZ: Apex Repel Natural; Electric Blue Headlice; Lice Blaster; Singapore: Burnaid; Rapaid†; T3; Tinasolve†; Thai.: Fungicon; Gynecon-T; UK: Dr Johnsons Nit & Lice; Sinose; Skin Clear; Tea Tree & Witch Hazel Cream; Teenstick.
Published May 08, 2019.