Lodoxamide Trometamol

Synonyms: Lodoksamid Trometamin; Lodoxamida trometamol; Lodoxamide Trométamol; Lodoxamide Tromethamine idum Trometamolum; U-42585E. N,N -(2-Chloro-5-cyanomphenylene)dioxamic acid compound with trometamol.
Cyrillic synonym: Лодоксамид Трометамол.

💊 Chemical information

Chemical formula: C11H6ClN3O6,2C4H11NO3 = 553.9.
CAS — 63610-09-3.
ATC — S01GX05.
ATC Vet — QS01GX05.

💊 Adverse Effects

Lodoxamide eye drops may cause local irritation. Reported effects include burning or stinging, and itching. Flushing and dizziness have also been reported.

💊 Uses and Administration

Lodoxamide has a stabilising action on mast cells resembling that of sodium cromoglicate. Lodoxamide trometamol is used in eye drops for allergic conjunctivitis, particularly vernal keratoconjunctivitis; a concentration equivalent to 0.1% of lodoxamide is used, 1 or 2 drops usually being instilled into the eye four times daily. Lodoxamide has also been studied for its prophylactic effect in the treatment of asthma, but has not proved to be of benefit; it has usually been given orally as the ethyl ester or by inhalation as the trometamol salt.


Lodoxamide is an effective treatment for vernal keratoconjunctivitis.1,2 There is some evidence that it may be more effective than sodium cromoglicate for this purpose.
1. Anonymous. Lodoxamide for vernal keratoconjunctivitis. Med Lett Drugs Ther 1994; 36: 26
2. Lee S, Allard TRFK. Lodoxamide in vernal keratoconjunctivitis. Ann Pharmacother 1996; 30: 535–7.

💊 Preparations

Proprietary Preparations

Arg.: Alomide; Austral.: Lomide; Austria: Alomide†; Belg.: Alomide; Braz.: Alomide; Canad.: Alomide; Chile: Alomide; Cz.: Alomide; Denm.: Alomide; Fin.: Alomide; Fr.: Almide; Ger.: Alomide; Gr.: Alomide; Thilomide; Hong Kong: Alomide; Hung.: Alomide; Indon.: Alomide; Irl.: Alomide; Israel: Alomide; Ital.: Alomide; Malaysia: Alomide; Mex.: Alomide; Norw.: Alomide; NZ: Lomide; Philipp.: Alconmide; Pol.: Alomide; Port.: Alomide; Rus.: Alomide (Аломид); S.Afr.: Alomide; Singapore: Alomide; Spain: Alomide; Switz.: Alomide†; Thai.: Alomide; Turk.: Alomide; Thilomide; UK: Alomide; USA: Alomide; Venez.: Alomide.
Published May 08, 2019.