Lixivaptan Chemical formula
Synonyms: Lixivaptán; Lixivaptanum; VPA-985; WAY-VPA-985. 3′-Chloro-5fluoro-4′-(5H-pyrrolo[2,1c][1,4]benzodiazepin-10(11H)-ylcarbonyl)o-toluanilide.
Cyrillic synonym: Ликсиваптан.

Chemical information

Chemical formula: C27H21ClFN3O2 = 473.9.
CAS — 168079-32-1.


Lixivaptan is a selective vasopressin V2-receptor antagonist under investigation for the treatment of hyponatraemia in patients with heart failure.
1. Abraham WT, et al. Aquaretic effect of lixivaptan, an oral, nonpeptide, selective V2 receptor vasopressin antagonist, in New York Heart Association functional class II and III chronic heart failure patients. J Am Coll Cardiol 2006; 47: 1615–21.
Published May 08, 2019.